TY - JOUR
T1 - Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
AU - Zinger, Assaf
AU - Soriano, Sirena
AU - Baudo, Gherardo
AU - De Rosa, Enrica
AU - Taraballi, Francesca
AU - Villapol, Sonia
N1 - Funding Information:
This work was supported by grants from the National Institute for Neurological Disorders and Stroke (NINDS), R21NS106640 (S.V.), TIRR Foundation through Mission Connect grant (S.V.), and funds from Houston Methodist Research Institute (S.V.). The authors thank Ms. Manuela Sushnitha, Ms. Shashi Krishnamurthy, Dr. Tomoyuki Naoi, and Ms. Eliana Stetco for their technical help. The authors are indebted to Dr.?Gillian Hamilton for editing the text. They thank the Baylor College of Medicine Cryo-TEM Core Facility for electronic imaging support and the Pathology and Histology Core (HTAP). Figure?1 was created using Biorender.com.
Funding Information:
This work was supported by grants from the National Institute for Neurological Disorders and Stroke (NINDS), R21NS106640 (S.V.), TIRR Foundation through Mission Connect grant (S.V.), and funds from Houston Methodist Research Institute (S.V.). The authors thank Ms. Manuela Sushnitha, Ms. Shashi Krishnamurthy, Dr. Tomoyuki Naoi, and Ms. Eliana Stetco for their technical help. The authors are indebted to Dr. Gillian Hamilton for editing the text. They thank the Baylor College of Medicine Cryo‐TEM Core Facility for electronic imaging support and the Pathology and Histology Core (HTAP). Figure 1 was created using Biorender.com.
Publisher Copyright:
© 2021 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/7/23
Y1 - 2021/7/23
N2 - Traumatic brain injury (TBI) triggers both central and peripheral inflammatory responses. Existing pharmacological drugs are unable to effectively and quickly target the brain inflamed regions, setting up a major roadblock towards effective brain trauma treatments. Nanoparticles (NPs) have been used in multiple diseases as drug delivery tools with remarkable success due to their rapid diffusion and specificity in the target organ. Here, leukocyte-based biomimetic NPs are fabricated as a theranostic tool to directly access inflamed regions in a TBI mouse model. This NP systemic delivery is visualized using advanced in vivo imaging techniques, including intravital microscopy and in vivo imaging system. The results demonstrate selective targeting of NPs to the injured brain and increased NPs accumulation among the peripheral organs 24 h after TBI. Interestingly, increased microglial proliferation, decreased macrophage infiltration, and reduced brain lesion following the NPs treatments compared to sham vehicle-treated mice are also found. In summary, the results suggest that NPs represent a promising future theranostic tool for TBI treatment.
AB - Traumatic brain injury (TBI) triggers both central and peripheral inflammatory responses. Existing pharmacological drugs are unable to effectively and quickly target the brain inflamed regions, setting up a major roadblock towards effective brain trauma treatments. Nanoparticles (NPs) have been used in multiple diseases as drug delivery tools with remarkable success due to their rapid diffusion and specificity in the target organ. Here, leukocyte-based biomimetic NPs are fabricated as a theranostic tool to directly access inflamed regions in a TBI mouse model. This NP systemic delivery is visualized using advanced in vivo imaging techniques, including intravital microscopy and in vivo imaging system. The results demonstrate selective targeting of NPs to the injured brain and increased NPs accumulation among the peripheral organs 24 h after TBI. Interestingly, increased microglial proliferation, decreased macrophage infiltration, and reduced brain lesion following the NPs treatments compared to sham vehicle-treated mice are also found. In summary, the results suggest that NPs represent a promising future theranostic tool for TBI treatment.
KW - biomimicry
KW - blood-brain barrier
KW - inflammation
KW - leukosomes
KW - liposomes
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U2 - 10.1002/adfm.202100722
DO - 10.1002/adfm.202100722
M3 - Article
C2 - 34413716
AN - SCOPUS:85103157668
SN - 1616-301X
VL - 31
SP - 2100722
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 30
M1 - 2100722
ER -