• Why do we need biomimicry? Which challenges does it aim to overcome? • Systemic delivery of free drugs has limitations. These limitations include rapid systemic clearance, inadequate levels of drug in the target tissue, poor solubility of some drugs, and increased off target toxicity. • Much effort has been invested into the development of different synthetic drug carriers. However, biomimetic carrier systems, inspired by the way different cells in our body behave, hold great therapeutic potential in addressing these challenges. • Several types of cells that interact with the vascular system, including erythrocytes, leukocytes, and thrombocytes, have inspired the design of new biomimetic carriers. • Inspired by native cells' biological functions, biomimetic nano-carrier platforms possess favorable properties such as: longer circulation times, mononuclear phagocyte system (MPS) evasion, and favorable interactions with target cells.

Original languageEnglish (US)
Article number102360
Pages (from-to)102360
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Early online dateJan 18 2021
StatePublished - Apr 2021


  • Animals
  • Biomimetic Materials/chemistry
  • Blood Platelets/chemistry
  • Cardiovascular Diseases/drug therapy
  • Cell Membrane Permeability
  • Delayed-Action Preparations/chemistry
  • Drug Liberation
  • Erythrocytes/chemistry
  • Humans
  • Leukocytes/chemistry
  • Molecular Targeted Therapy
  • Nanocapsules/chemistry
  • Surface Properties

ASJC Scopus subject areas

  • Bioengineering
  • Molecular Medicine
  • Materials Science(all)
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Pharmaceutical Science


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