Biomimetic Mg-substituted hydroxyapatite: From synthesis to in vivo behaviour

Elena Landi, Giandomenico Logroscino, Luca Proietti, Anna Tampieri, Monica Sandri, Simone Sprio

Research output: Contribution to journalArticlepeer-review

336 Scopus citations


The incorporation of magnesium ions (in the range 5-10 mol% in respect to Ca) into the hydroxyapatite structure, which is of great interest for the developing of artificial bone, was performed using magnesium chloride, calcium hydroxide and phosphoric acid, as reactants. Among the synthesized powders, the synthetic HA powder containing 5.7% Mg substituting for calcium was selected, due to its better chemico-physical features, and transformed into granules of 400-600 μm, for biocompatibility tests (genotoxicity, carcinogenicity, toxicity, in vitro cytotoxicity and in vivo skin irritation-sensitization tests). In vivo tests were carried out on New Zealand White rabbits using the granulate as filling for a femoral bone defect: osteoconductivity and resorption were found to be enhanced compared to commercial stoichiometric HA granulate, taken as control.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalJournal of Materials Science: Materials in Medicine
Issue number1
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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