Biomimetic Metal–Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy

Huan Min, Jing Wang, Yingqiu Qi, Yinlong Zhang, Xuexiang Han, Ying Xu, Junchao Xu, Yao Li, Long Chen, Keman Cheng, Guangna Liu, Na Yang, Yiye Li, Guangjun Nie

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Photodynamic therapy (PDT) is a promising anticancer treatment and is clinically approved for different types of tumors. However, current PDT suffers several obstacles, including its neutralization by excess glutathione (GSH) in the tumor tissue and its strongly proangiogenic tumor response. In this work, a biomimic, multifunctional nanoparticle-based PDT agent, combining a tumor-targeted photosensitizer with GSH scavenging and antiangiogenesis therapy, is developed. A porphyrinic Zr–metal–organic framework nanoparticle is used simultaneously as the photosensitizer and the delivery vehicle of vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor apatinib. The core nanoparticles are wrapped in MnO 2 to consume the intratumoral GSH and then decorated with a tumor cell membrane camouflage. After intravenous administration, the nanoparticles selectively accumulate in tumor through homotypic targeting mediated by the biomimic decoration, and the combination of enhanced PDT and antiangiogenic drug significantly improves their tumor inhibition efficiency. This study provides an integrated solution for mechanism-based enhancement of PDT and demonstrates the encouraging potential for multifunctional nanosystem applicable for tumor therapy.

Original languageEnglish (US)
Article number1808200
JournalAdvanced Materials
Volume31
Issue number15
DOIs
StatePublished - Apr 12 2019

Keywords

  • MOF
  • angiogenesis inhibition
  • biomimetic nanoparticle
  • glutathione metabolism
  • photodynamic therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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