Biomimetic hydroxyapatite particulate nanofiber modified silicon: In vitro bioactivity

Santosh Aryal; Madhab Prasad Bajgai; Seob Khil Myung; Hyung Sub Kang; Kim Hak Yong

doi:10.1002/jbm.a.31779

Biomimetic hydroxyapatite particulate nanofiber modified silicon: In vitro bioactivity

Santosh Aryal, Madhab Prasad Bajgai, Seob Khil Myung, Hyung Sub Kang, Kim Hak Yong

Houston Methodist

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

A novel particulate nanofibrous hydroxyapatite (HA), which mimics the bone matrix, is presented as a surface functional material to modify silicon wafers by the electrospinning method. The HA precursors were treated with viscous polymer solution, and then electrospun under controlled conditions. After successive calcinations, the powder X-ray diffraction patterns of the samples revealed reflection toward the (300) HA plane that is linear with temperature. This prominent reflection suggests the crystallography purity of the HA. Biocompatibility, cell proliferation, and microstructure were examined using AFM and FE-SEM. Morphology showed cell spreading and penetration instead of cell aggregation. The surface roughness as well as adhesion force was calculated using contact mode AFM. The results show that the composite matrix holds promise for use as a bone implant material.

Original language	English (US)
Pages (from-to)	384-391
Number of pages	8
Journal	Journal of Biomedical Materials Research - Part A
Volume	88
Issue number	2
DOIs	https://doi.org/10.1002/jbm.a.31779
State	Published - Feb 1 2009

Keywords

Electrospinning
Hydroxyapatite
Nanofiber
Osteoblast
Silicon

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Ceramics and Composites
Metals and Alloys

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10.1002/jbm.a.31779

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title = "Biomimetic hydroxyapatite particulate nanofiber modified silicon: In vitro bioactivity",

abstract = "A novel particulate nanofibrous hydroxyapatite (HA), which mimics the bone matrix, is presented as a surface functional material to modify silicon wafers by the electrospinning method. The HA precursors were treated with viscous polymer solution, and then electrospun under controlled conditions. After successive calcinations, the powder X-ray diffraction patterns of the samples revealed reflection toward the (300) HA plane that is linear with temperature. This prominent reflection suggests the crystallography purity of the HA. Biocompatibility, cell proliferation, and microstructure were examined using AFM and FE-SEM. Morphology showed cell spreading and penetration instead of cell aggregation. The surface roughness as well as adhesion force was calculated using contact mode AFM. The results show that the composite matrix holds promise for use as a bone implant material.",

keywords = "Electrospinning, Hydroxyapatite, Nanofiber, Osteoblast, Silicon",

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AU - Myung, Seob Khil

AU - Kang, Hyung Sub

AU - Yong, Kim Hak

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