BioMEMS for drug delivery applications

J. R. Lewis, Mauro Ferrari

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

This chapter delineates current efforts for the development of novel, micro technology assisted modalities for the delivery of pharmaceuticals, which may help address the needs. Biodegradable polymer nanoparticles can provide sustained release from layers of diffuse drugs. Remote controlled-release may include sensing magnetic fields ultrasound and electric current which in itself naturally suggests the integration of microelectromechanical systems (MEMS) and bioMEMS technologies on the drug-delivery platform. The chapter also focuses on reviewing current micro technology-based drug-delivery devices and enabling technologies, and in particular micro fabricated needles, nanoporous membranes, implantable devices, and microcapsules for oral and parenteral drug delivery. Drug delivery technology is envisioned to support new neuro pharmacology research for treatment of neurological disorders. The implantable drug-delivery system incorporates multiple complex functionalities that can allow for self or remotely regulated dispensation of precisely controlled therapeutic agents. A large number of new biological drugs are being discovered, developed, and licensed that translates into expected further growth of the pharmaceutical market and the demand for alternative drug delivery device.

Original languageEnglish (US)
Title of host publicationLab-on-a-Chip
Subtitle of host publicationMiniaturized Systems for (Bio) Chemical Analysis and Synthesis
PublisherElsevier
Pages373-389
Number of pages17
ISBN (Print)9780444511003
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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