TY - JOUR
T1 - Biomembrane-based nanostructures for cancer targeting and therapy
T2 - From synthetic liposomes to natural biomembranes and membrane-vesicles
AU - Wang, Jing
AU - Zhu, Motao
AU - Nie, Guangjun
N1 - Funding Information:
This work was supported by the National Basic Research Plan of China (2018YFA0208900), the National Key R&D Program of China (2018YFE0205300), the Strategic Priority Research Program of Chinese Academy of Sciences (XDB36000000), the Key Research Program of Frontier Sciences CAS (ZDBS-LY-SLH039), the K. C. Wong Education Foundation (GJTD-2018-03) and the National Center for Nanoscience and Technology of China (E1773911).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/11
Y1 - 2021/11
N2 - The translational success of liposomes in chemotherapeutics has already demonstrated the great potential of biomembrane-based nanostructure in effective drug delivery. Meanwhile, increasing efforts are being dedicated to the application of naturally derived lipid membranes, including cellular membranes and extracellular vesicles in anti-cancer therapies. While synthetic liposomes support superior multifunctional flexibility, natural biomembrane materials possess interesting biomimetic properties and can also be further engineered for intelligent design. Despite being remarkably different from each other in production and composition, the phospholipid bilayer structure in common allows liposomes, cell membrane-derived nanomaterials, and extracellular vesicles to be modified, functionalized, and exploited in many similar manners against challenges posed by tumor-targeted drug delivery. This review will summarize the recent advancements in engineering the membrane-derived nanostructures with “intelligent” modules to respond, regulate, and target tumor cells and the microenvironment to fight against malignancy. We will also discuss perspectives of combining engineered functionalities with naturally occurring activity for enhanced cancer therapy.
AB - The translational success of liposomes in chemotherapeutics has already demonstrated the great potential of biomembrane-based nanostructure in effective drug delivery. Meanwhile, increasing efforts are being dedicated to the application of naturally derived lipid membranes, including cellular membranes and extracellular vesicles in anti-cancer therapies. While synthetic liposomes support superior multifunctional flexibility, natural biomembrane materials possess interesting biomimetic properties and can also be further engineered for intelligent design. Despite being remarkably different from each other in production and composition, the phospholipid bilayer structure in common allows liposomes, cell membrane-derived nanomaterials, and extracellular vesicles to be modified, functionalized, and exploited in many similar manners against challenges posed by tumor-targeted drug delivery. This review will summarize the recent advancements in engineering the membrane-derived nanostructures with “intelligent” modules to respond, regulate, and target tumor cells and the microenvironment to fight against malignancy. We will also discuss perspectives of combining engineered functionalities with naturally occurring activity for enhanced cancer therapy.
KW - Cancer immunotherapy
KW - Cancer vaccine
KW - Cell membrane camouflages
KW - Extracellular vesicles
KW - Gene therapy
KW - Multifunctional liposomes
KW - Tumor microenvironment
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U2 - 10.1016/j.addr.2021.113974
DO - 10.1016/j.addr.2021.113974
M3 - Review article
C2 - 34530015
AN - SCOPUS:85115189725
SN - 0169-409X
VL - 178
SP - 113974
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 113974
ER -