Biomechanical properties of synthetic and biologic graft materials following long-term implantation in the rabbit abdomen and vagina

Lisa M. Pierce, Melissa A. Grunlan, Yaping Hou, Shannon S. Baumann, Thomas J. Kuehl, Tristi W. Muir

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Objective: We sought to evaluate the effects of anatomic location and ovariectomy on biomechanical properties of synthetic and biologic graft materials after long-term implantation. Study Design: A total of 35 rabbits underwent ovariectomy or sham laparotomy and were implanted with polypropylene (PP) mesh (n = 17) or cross-linked porcine dermis (PS) (n = 18) in the vagina and abdomen. Grafts were harvested 9 months later and underwent mechanical properties testing. Results: After implantation, PS was similar in strength (P = .52) but was twice as stiff as PP (P = .04) and had a maximal elongation only half that of PP (P < .001). Degradation of PS was associated with decreased ultimate tensile strength (P = .03) and elastic modulus (P = .046). Vaginal PP grafts shrunk more (P < .001) and were less stiff than abdominal PP grafts (P = .049) but were not different in strength (P = .19). Ovariectomy had no effect (P > .05). Conclusion: Cross-linked PS undergoes long-term degradation resulting in compromised biomechanical properties and thus is likely inferior to lightweight PP meshes for pelvic organ prolapse and incontinence procedures.

Original languageEnglish (US)
Pages (from-to)549.e1-549.e8
JournalAmerican Journal of Obstetrics and Gynecology
Volume200
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • biologic graft
  • pelvic organ prolapse
  • polypropylene mesh
  • porcine dermis
  • rabbit model
  • synthetic graft

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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