Biomarkers for selection of therapy for adenocarcinoma of the lung

Eric H. Bernicker, Ross A. Miller, Phillip T. Cagle

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

To suggest that the discovery of targetable driver mutations in many patients with advanced adenocarcinoma of the lung has completely transformed the work-up and therapeutic options for this disease would not be hyperbole. Although not curative, smallmolecule tyrosine kinase inhibitors directed at oncogene-Addicted tumors have led to significantly improved response rates compared with cytotoxic chemotherapy, with often manageable toxicities and better tolerance. However, the absence of reliable clinical predictors has made molecular testing essential to ensure that patients receive the proper medical management. We outline the many recent advances with regard to diagnosis and treatment of oncogene-Addicted advanced nonsquamous non-small-cell lung cancer.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalJournal of oncology practice
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2017

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)
  • Health Policy

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