Biomarkers for Parkinson’s Disease: How Good Are They?

Tianbai Li, Weidong Le

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Parkinson’s disease (PD) is a complex neurodegenerative disorder with no cure in sight. Clinical challenges of the disease include the inability to make a definitive diagnosis at the early stages and difficulties in predicting the disease progression. The unmet demand to identify reliable biomarkers for early diagnosis and management of the disease course of PD has attracted a lot of attention. However, only a few reported candidate biomarkers have been tried in clinical practice at the present time. Studies on PD biomarkers have often overemphasized the discovery of novel identity, whereas efforts to further evaluate such candidates are rare. Therefore, we update the new development of biomarker discovery in PD and discuss the standard process in the evaluation and assessment of the diagnostic or prognostic value of the identified potential PD biomarkers in this review article. Recent developments in combined biomarkers and the current status of clinical trials of biomarkers as outcome measures are also discussed. We believe that the combination of different biomarkers might enhance the specificity and sensitivity over a single measure that might not be sufficient for such a multiplex disease.

Original languageEnglish (US)
Pages (from-to)183-194
Number of pages12
JournalNeuroscience Bulletin
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • Biomarkers
  • Clinical trials
  • Combined biomarkers
  • Parkinson’s disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'Biomarkers for Parkinson’s Disease: How Good Are They?'. Together they form a unique fingerprint.

Cite this