Bioluminescence imaging of stem cell-based therapeutics for vascular regeneration

Ngan F. Huang, Janet Okogbaa, Anna Babakhanyan, John P. Cooke

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Stem cell-based therapeutics show promise for treatment of vascular diseases. However, the survival of the cells after in vivo injection into diseased tissues remains a concern. In the advent of non-invasive optical imaging techniques such as bioluminescence imaging (BLI), cell locali-zation and survival can be easily monitored over time. This approach has recently been applied towards monitoring stem cell treatments for vascular regeneration of the coronary or pe-ripheral arteries. In this review, we will describe the application of BLI for tracking trans-planted stem cells and associating their viability with therapeutic efficacy, in preclinical disease models of vascular disease.

Original languageEnglish (US)
Pages (from-to)346-354
Number of pages9
JournalTheranostics
Volume2
Issue number4
DOIs
StatePublished - 2012

Keywords

  • Bioluminescence
  • Embryonic stem cell
  • Induced pluripotent stem cell
  • Myocardial infarction
  • Peripheral arterial disease
  • Vascular regeneration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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