Biology of aortic aneurysms and dissections.

Joseph S. Fernandez-Moure; Daynene Vykoukal; Mark G. Davies

doi:10.14797/mdcj-7-3-2

Biology of aortic aneurysms and dissections.

Joseph S. Fernandez-Moure, Daynene Vykoukal, Mark G. Davies

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.

Original language	English (US)
Pages (from-to)	2-7
Number of pages	6
Journal	Methodist DeBakey cardiovascular journal
Volume	7
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-7-3-2
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Biology of aortic aneurysms and dissections.",

abstract = "The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.",

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AB - The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.

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Biology of aortic aneurysms and dissections.

Abstract

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