TY - JOUR
T1 - Biological targeting and innovative therapeutic interventions with phage-displayed peptides and structured nucleic acids (aptamers)
AU - Ahmadvand, Davoud
AU - Rahbarizadeh, Fatemeh
AU - Moghimi, Seyed Moein
N1 - Funding Information:
Financial support by the Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsråd) reference 09-065746/DSF is gratefully acknowledged.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - Diverse technologies such as phage display, cell systematic evolution of ligands by exponential enrichment and related modifications thereof are generating a wide range of peptide-based and structured nucleic acid (aptamers)-based ligands for therapeutic and diagnostic interventions in an unbiased biological context. Their impressive affinity and unprecedented target specificity make these ligands as ideal small-sized candidates for conjugation to macromolecules and nanoparticulate matters, thus opening the path to new and sophisticated design solutions for targeted therapy, disease detection and diagnosis. Vascular beds of many organs and tissue, cancer, immune and stem cells are among the key targets. These technologies are evaluated and selected recent examples of innovative biological targeting and therapeutic interventions with phage-displayed peptides and aptamers are discussed.
AB - Diverse technologies such as phage display, cell systematic evolution of ligands by exponential enrichment and related modifications thereof are generating a wide range of peptide-based and structured nucleic acid (aptamers)-based ligands for therapeutic and diagnostic interventions in an unbiased biological context. Their impressive affinity and unprecedented target specificity make these ligands as ideal small-sized candidates for conjugation to macromolecules and nanoparticulate matters, thus opening the path to new and sophisticated design solutions for targeted therapy, disease detection and diagnosis. Vascular beds of many organs and tissue, cancer, immune and stem cells are among the key targets. These technologies are evaluated and selected recent examples of innovative biological targeting and therapeutic interventions with phage-displayed peptides and aptamers are discussed.
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U2 - 10.1016/j.copbio.2011.02.012
DO - 10.1016/j.copbio.2011.02.012
M3 - Review article
C2 - 21420292
AN - SCOPUS:81855164638
VL - 22
SP - 832
EP - 838
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 6
ER -