Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.

Ismail M. Meraz, Victor Segura-Ibarra, Fransisca Leonard, Javier Gonzalez, Sally Ally, Biana Godin, Rita Serda

Research output: Contribution to journalArticle

Abstract

Discrete pathologies have unique features that contribute to disease progression. Each lesion contains unique clusters of cells and other factors that make up specific micro-niches. Individual microniches present novel barriers that hamper the delivery of therapeutics, but it also contains characteristic elements that can favour accumulation of therapeutics within the lesion. This chapter discusses the unique biology associated with cancer, cardiovascular disease, and neurological disorders and describes how each unique presentation can be used to optimize nanoparticle design for targeting the lesion.

Original languageEnglish
Pages (from-to)139-173
Number of pages35
JournalFrontiers of Nanoscience
Volume5
DOIs
StatePublished - Sep 25 2013

Keywords

  • Biological barrier
  • Cancer
  • Cardiovascular disease
  • Drug delivery
  • Immunotherapy
  • Microenvironment
  • Nanoparticle
  • Neurology disorder

ASJC Scopus subject areas

  • Materials Science(all)
  • Biomedical Engineering
  • Bioengineering

Fingerprint Dive into the research topics of 'Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.'. Together they form a unique fingerprint.

Cite this