Biodistribution of carbon single-wall carbon nanotubes in mice

Haifang Wang, Jing Wang, Xiaoyong Deng, Hongfang Sun, Zujin Shi, Zhennan Gu, Yuanfang Liu, Yuliang Zhao

Research output: Contribution to journalArticle

330 Scopus citations

Abstract

Carbon nanotubes are promising for use in biomedical and pharmaceutical sciences. Therefore, it becomes imperative to know the basic biological properties of carbon nanotubes in vivo. We labeled the water-soluble hydroxylated carbon single-wall nanotubes with radioactive 125I atoms, and then the tracer was used to study the distribution of hydroxylated carbon single-wall nanotubes in mice. They moved easily among the compartments and tissues of the body, behaving as small active molecules though their apparent mean molecular weight is tremendously large. This study, for the first time, affords a quantitative analysis of carbon nanotubes accumulated in animal tissues.

Original languageEnglish (US)
Article number006
Pages (from-to)1019-1024
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume4
Issue number8
DOIs
StatePublished - Nov 1 2004

Keywords

  • I-labeling
  • Carbon Single-Wall Nanotubes
  • Distribution
  • In vivo
  • Water-Soluble

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Materials Science (miscellaneous)
  • Engineering (miscellaneous)

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