Biocompatibility assessment of Si-based nano- and micro-particles

Hamsa Jaganathan; Biana Godin

doi:10.1016/j.addr.2012.05.008

Biocompatibility assessment of Si-based nano- and micro-particles

Hamsa Jaganathan, Biana Godin

Research output: Contribution to journal › Review article › peer-review

243 Scopus citations

Abstract

Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engineering/medicine. This review summarizes studies on effects of silicon and silica nano- and micro-particles on cells and organs following four main exposure routes, namely, intravenous, pulmonary, dermal and oral. Further, possible genotoxic effects of silica based nanoparticles are discussed. The review concludes with an outlook on improving and standardizing biocompatibility assessment for nano- and micro-particles.

Original language	English (US)
Pages (from-to)	1800-1819
Number of pages	20
Journal	Advanced Drug Delivery Reviews
Volume	64
Issue number	15
DOIs	https://doi.org/10.1016/j.addr.2012.05.008
State	Published - Dec 2012

Keywords

Biocompatibility
Mesoporous
Nanomaterials
Silica
Silicon
Toxicity

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.addr.2012.05.008

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title = "Biocompatibility assessment of Si-based nano- and micro-particles",

abstract = "Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engineering/medicine. This review summarizes studies on effects of silicon and silica nano- and micro-particles on cells and organs following four main exposure routes, namely, intravenous, pulmonary, dermal and oral. Further, possible genotoxic effects of silica based nanoparticles are discussed. The review concludes with an outlook on improving and standardizing biocompatibility assessment for nano- and micro-particles.",

keywords = "Biocompatibility, Mesoporous, Nanomaterials, Silica, Silicon, Toxicity",

author = "Hamsa Jaganathan and Biana Godin",

note = "Funding Information: We would like to thank Srimeenakshi Srinivasan and Fransisca Leonard for their informative discussions on the manuscript. We also would like to thank Matthew Landry for his assistance with graphics in the manuscript. The authors acknowledge a financial support from the following sources: Susan G. Komen Postdoctoral Fellowship \# PDF12229449 , NIH U54CA143837 (CTO, PS-OC), NIH 1U54CA151668-01 (TCCN, CCNE), DOD W81XWH-09-1-0212 and DOD W81XWH-11-02-0168 .",

year = "2012",

month = dec,

doi = "10.1016/j.addr.2012.05.008",

language = "English (US)",

volume = "64",

pages = "1800--1819",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

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T1 - Biocompatibility assessment of Si-based nano- and micro-particles

AU - Jaganathan, Hamsa

AU - Godin, Biana

N1 - Funding Information: We would like to thank Srimeenakshi Srinivasan and Fransisca Leonard for their informative discussions on the manuscript. We also would like to thank Matthew Landry for his assistance with graphics in the manuscript. The authors acknowledge a financial support from the following sources: Susan G. Komen Postdoctoral Fellowship # PDF12229449 , NIH U54CA143837 (CTO, PS-OC), NIH 1U54CA151668-01 (TCCN, CCNE), DOD W81XWH-09-1-0212 and DOD W81XWH-11-02-0168 .

PY - 2012/12

Y1 - 2012/12

N2 - Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engineering/medicine. This review summarizes studies on effects of silicon and silica nano- and micro-particles on cells and organs following four main exposure routes, namely, intravenous, pulmonary, dermal and oral. Further, possible genotoxic effects of silica based nanoparticles are discussed. The review concludes with an outlook on improving and standardizing biocompatibility assessment for nano- and micro-particles.

AB - Silicon is one of the most abundant chemical elements found on the Earth. Due to its unique chemical and physical properties, silicon based materials and their oxides (e.g. silica) have been used in several industries such as building and construction, electronics, food industry, consumer products and biomedical engineering/medicine. This review summarizes studies on effects of silicon and silica nano- and micro-particles on cells and organs following four main exposure routes, namely, intravenous, pulmonary, dermal and oral. Further, possible genotoxic effects of silica based nanoparticles are discussed. The review concludes with an outlook on improving and standardizing biocompatibility assessment for nano- and micro-particles.

KW - Biocompatibility

KW - Mesoporous

KW - Nanomaterials

KW - Silica

KW - Silicon

KW - Toxicity

UR - https://www.scopus.com/pages/publications/84869155482

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U2 - 10.1016/j.addr.2012.05.008

DO - 10.1016/j.addr.2012.05.008

M3 - Review article

C2 - 22634160

AN - SCOPUS:84869155482

SN - 0169-409X

VL - 64

SP - 1800

EP - 1819

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 15

ER -

Biocompatibility assessment of Si-based nano- and micro-particles

Abstract

Keywords

ASJC Scopus subject areas

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