Biocompatibility and biofunctionality of a gelatin impregnated polyester arterial prosthesis

Nabil Chakfe; Yves Marois; Robert Guidoin; Xiaoyan Deng; Michel Marois; Raynald Roy; Martin King; Yvan Douville

Biocompatibility and biofunctionality of a gelatin impregnated polyester arterial prosthesis

Nabil Chakfe, Yves Marois, Robert Guidoin, Xiaoyan Deng, Michel Marois, Raynald Roy, Martin King, Yvan Douville

Research output: Contribution to journal › Article › peer-review

Abstract

The gelatin-impregnated vascular graft Gelsealqq and its parent Triaxialqq graft were evaluated in terms of biocompatibility in rats and vivo biofunctionality as a thoraco-abdominal bypass in dogs. The Gelseal graft induced a significant reduction of T helper cells (CD4), while the Triaxial graft showed similar results to the control group (wounded rats without prosthesis) with a slight reduction of CD4 cells. Although, the impregnated graft showed an inflammatory reaction which lasted slightly longer than the control group, the reaction of both grafts became chronic and moderate after 2 weeks. There was only a slight difference in the healing characteristics and, fibrin and platelet uptake of the impregnated and non-impregnated grafts.

Original language	English (US)
Pages (from-to)	229-251
Number of pages	23
Journal	Polymers and Polymer Composites
Volume	1
Issue number	4
State	Published - Dec 1 1993

ASJC Scopus subject areas

Ceramics and Composites
Polymers and Plastics
Materials Chemistry

Cite this

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abstract = "The gelatin-impregnated vascular graft Gelsealqq and its parent Triaxialqq graft were evaluated in terms of biocompatibility in rats and vivo biofunctionality as a thoraco-abdominal bypass in dogs. The Gelseal graft induced a significant reduction of T helper cells (CD4), while the Triaxial graft showed similar results to the control group (wounded rats without prosthesis) with a slight reduction of CD4 cells. Although, the impregnated graft showed an inflammatory reaction which lasted slightly longer than the control group, the reaction of both grafts became chronic and moderate after 2 weeks. There was only a slight difference in the healing characteristics and, fibrin and platelet uptake of the impregnated and non-impregnated grafts.",

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AU - Chakfe, Nabil

AU - Marois, Yves

AU - Guidoin, Robert

AU - Deng, Xiaoyan

AU - Marois, Michel

AU - Roy, Raynald

AU - King, Martin

AU - Douville, Yvan

PY - 1993/12/1

Y1 - 1993/12/1

N2 - The gelatin-impregnated vascular graft Gelsealqq and its parent Triaxialqq graft were evaluated in terms of biocompatibility in rats and vivo biofunctionality as a thoraco-abdominal bypass in dogs. The Gelseal graft induced a significant reduction of T helper cells (CD4), while the Triaxial graft showed similar results to the control group (wounded rats without prosthesis) with a slight reduction of CD4 cells. Although, the impregnated graft showed an inflammatory reaction which lasted slightly longer than the control group, the reaction of both grafts became chronic and moderate after 2 weeks. There was only a slight difference in the healing characteristics and, fibrin and platelet uptake of the impregnated and non-impregnated grafts.

AB - The gelatin-impregnated vascular graft Gelsealqq and its parent Triaxialqq graft were evaluated in terms of biocompatibility in rats and vivo biofunctionality as a thoraco-abdominal bypass in dogs. The Gelseal graft induced a significant reduction of T helper cells (CD4), while the Triaxial graft showed similar results to the control group (wounded rats without prosthesis) with a slight reduction of CD4 cells. Although, the impregnated graft showed an inflammatory reaction which lasted slightly longer than the control group, the reaction of both grafts became chronic and moderate after 2 weeks. There was only a slight difference in the healing characteristics and, fibrin and platelet uptake of the impregnated and non-impregnated grafts.

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Biocompatibility and biofunctionality of a gelatin impregnated polyester arterial prosthesis

Abstract

ASJC Scopus subject areas

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