Biocompatibility and biofunctionality of a gelatin impregnated polyester arterial prosthesis

Nabil Chakfe, Yves Marois, Robert Guidoin, Xiaoyan Deng, Michel Marois, Raynald Roy, Martin King, Yvan Douville

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The gelatin-impregnated vascular graft Gelsealqq and its parent Triaxialqq graft were evaluated in terms of biocompatibility in rats and vivo biofunctionality as a thoraco-abdominal bypass in dogs. The Gelseal graft induced a significant reduction of T helper cells (CD4), while the Triaxial graft showed similar results to the control group (wounded rats without prosthesis) with a slight reduction of CD4 cells. Although, the impregnated graft showed an inflammatory reaction which lasted slightly longer than the control group, the reaction of both grafts became chronic and moderate after 2 weeks. There was only a slight difference in the healing characteristics and, fibrin and platelet uptake of the impregnated and non-impregnated grafts.

Original languageEnglish (US)
Pages (from-to)229-251
Number of pages23
JournalPolymers and Polymer Composites
Volume1
Issue number4
StatePublished - Dec 1 1993

ASJC Scopus subject areas

  • Ceramics and Composites
  • Polymers and Plastics
  • Materials Chemistry

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