Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows

D. Jones; S. Safe; E. Morcom; M. Holcomb; C. Coppock; W. Ivie

doi:10.1016/0045-6535(87)90161-5

Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows

D. Jones, S. Safe, E. Morcom, M. Holcomb, C. Coppock, W. Ivie

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

Holstein dairy cows weighing from 500 to 650 kg were given tritiated TCDD on crushed grain at a dosage level of either 75 or 0.05 μg/kg body weight, per os. The higher dosed animal was killed on day 7 while the 2 lower dosed animals were killed on day 14. In both the high and low dosed animals, radioactivity was eliminated mainly in the feces, but also in milk and urine. The major portion of the administered dose was eliminated via these routes in the first several days post-treatment. Tissue residues were found to be the highest in fat, followed by liver, kidney, muscle and brain.

Original language	English (US)
Pages (from-to)	1743-1748
Number of pages	6
Journal	Chemosphere
Volume	16
Issue number	8-9
DOIs	https://doi.org/10.1016/0045-6535(87)90161-5
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Chemistry(all)
Pollution
Health, Toxicology and Mutagenesis

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title = "Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows",

abstract = "Holstein dairy cows weighing from 500 to 650 kg were given tritiated TCDD on crushed grain at a dosage level of either 75 or 0.05 μg/kg body weight, per os. The higher dosed animal was killed on day 7 while the 2 lower dosed animals were killed on day 14. In both the high and low dosed animals, radioactivity was eliminated mainly in the feces, but also in milk and urine. The major portion of the administered dose was eliminated via these routes in the first several days post-treatment. Tissue residues were found to be the highest in fat, followed by liver, kidney, muscle and brain.",

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AU - Safe, S.

AU - Morcom, E.

AU - Holcomb, M.

AU - Coppock, C.

AU - Ivie, W.

PY - 1987

Y1 - 1987

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