Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows

D. Jones; S. Safe; E. Morcom; M. Holcomb; C. Coppock; W. Ivie

doi:10.1016/0045-6535(87)90161-5

Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows

D. Jones, S. Safe, E. Morcom, M. Holcomb, C. Coppock, W. Ivie

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Holstein dairy cows weighing from 500 to 650 kg were given tritiated TCDD on crushed grain at a dosage level of either 75 or 0.05 μg/kg body weight, per os. The higher dosed animal was killed on day 7 while the 2 lower dosed animals were killed on day 14. In both the high and low dosed animals, radioactivity was eliminated mainly in the feces, but also in milk and urine. The major portion of the administered dose was eliminated via these routes in the first several days post-treatment. Tissue residues were found to be the highest in fat, followed by liver, kidney, muscle and brain.

Original language	English (US)
Pages (from-to)	1743-1748
Number of pages	6
Journal	Chemosphere
Volume	16
Issue number	8-9
DOIs	https://doi.org/10.1016/0045-6535(87)90161-5
State	Published - 1987

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1016/0045-6535(87)90161-5

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title = "Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows",

abstract = "Holstein dairy cows weighing from 500 to 650 kg were given tritiated TCDD on crushed grain at a dosage level of either 75 or 0.05 μg/kg body weight, per os. The higher dosed animal was killed on day 7 while the 2 lower dosed animals were killed on day 14. In both the high and low dosed animals, radioactivity was eliminated mainly in the feces, but also in milk and urine. The major portion of the administered dose was eliminated via these routes in the first several days post-treatment. Tissue residues were found to be the highest in fat, followed by liver, kidney, muscle and brain.",

author = "D. Jones and S. Safe and E. Morcom and M. Holcomb and C. Coppock and W. Ivie",

note = "Funding Information: This work was supported by the U.S. Environmental Protection Agency cooperative agreement CR812614-01 and the Texas Agricultural Experiment Station, $6617, but does not necessarily reflect the views of these agencies. No official endorsement should be inferred.",

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T1 - Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows

AU - Jones, D.

AU - Safe, S.

AU - Morcom, E.

AU - Holcomb, M.

AU - Coppock, C.

AU - Ivie, W.

N1 - Funding Information: This work was supported by the U.S. Environmental Protection Agency cooperative agreement CR812614-01 and the Texas Agricultural Experiment Station, $6617, but does not necessarily reflect the views of these agencies. No official endorsement should be inferred.

PY - 1987

Y1 - 1987

N2 - Holstein dairy cows weighing from 500 to 650 kg were given tritiated TCDD on crushed grain at a dosage level of either 75 or 0.05 μg/kg body weight, per os. The higher dosed animal was killed on day 7 while the 2 lower dosed animals were killed on day 14. In both the high and low dosed animals, radioactivity was eliminated mainly in the feces, but also in milk and urine. The major portion of the administered dose was eliminated via these routes in the first several days post-treatment. Tissue residues were found to be the highest in fat, followed by liver, kidney, muscle and brain.

AB - Holstein dairy cows weighing from 500 to 650 kg were given tritiated TCDD on crushed grain at a dosage level of either 75 or 0.05 μg/kg body weight, per os. The higher dosed animal was killed on day 7 while the 2 lower dosed animals were killed on day 14. In both the high and low dosed animals, radioactivity was eliminated mainly in the feces, but also in milk and urine. The major portion of the administered dose was eliminated via these routes in the first several days post-treatment. Tissue residues were found to be the highest in fat, followed by liver, kidney, muscle and brain.

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Bioavailability of tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to Holstein dairy cows

Abstract

ASJC Scopus subject areas

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