TY - JOUR
T1 - Bioavailability of grain and soil-borne tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to lactating Holstein cows
AU - Jones, D.
AU - Safe, S.
AU - Morcom, E.
AU - Holcomb, M.
AU - Coppock, C.
AU - Ivie, W.
N1 - Funding Information:
This work was supported by the U.S. Environmental Protection Agency cooperative agreement CR812614-01 and the Texas Agricultural Experiment Station, $6617, but does not necessarily reflect the views of these agencies. No official endorsement should be inferred.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - Holstein dairy cows weighing from 488 to 650 kg were given tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on crushed grain or Gerald silt loam soil as a single oral dose of 0.05 ug/kg body weight. The cows were killed 14 days posttreatment. In both the grain- and soil-treated animals, tissue residues were highest in the fat, followed by liver, kidney, muscle and brain. Secretion of radioactivity into milk was highest during the first 3-4 days posttreatment with only small quantities being secreted into the milk during the following 10 days. Hepatic aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase appeared to be slightly elevated 14 days after treatment with either grain or soil-borne TCDD. The aryl hydrocarbon (Ah) receptor was not detected using the hydroxylapatite assay procedure.
AB - Holstein dairy cows weighing from 488 to 650 kg were given tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on crushed grain or Gerald silt loam soil as a single oral dose of 0.05 ug/kg body weight. The cows were killed 14 days posttreatment. In both the grain- and soil-treated animals, tissue residues were highest in the fat, followed by liver, kidney, muscle and brain. Secretion of radioactivity into milk was highest during the first 3-4 days posttreatment with only small quantities being secreted into the milk during the following 10 days. Hepatic aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase appeared to be slightly elevated 14 days after treatment with either grain or soil-borne TCDD. The aryl hydrocarbon (Ah) receptor was not detected using the hydroxylapatite assay procedure.
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U2 - 10.1016/0045-6535(89)90263-4
DO - 10.1016/0045-6535(89)90263-4
M3 - Article
AN - SCOPUS:0024360029
SN - 0045-6535
VL - 18
SP - 1257
EP - 1263
JO - Chemosphere
JF - Chemosphere
IS - 1-6
ER -