Bioavailability of grain and soil-borne tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered to lactating Holstein cows

D. Jones, S. Safe, E. Morcom, M. Holcomb, C. Coppock, W. Ivie

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Holstein dairy cows weighing from 488 to 650 kg were given tritiated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on crushed grain or Gerald silt loam soil as a single oral dose of 0.05 ug/kg body weight. The cows were killed 14 days posttreatment. In both the grain- and soil-treated animals, tissue residues were highest in the fat, followed by liver, kidney, muscle and brain. Secretion of radioactivity into milk was highest during the first 3-4 days posttreatment with only small quantities being secreted into the milk during the following 10 days. Hepatic aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase appeared to be slightly elevated 14 days after treatment with either grain or soil-borne TCDD. The aryl hydrocarbon (Ah) receptor was not detected using the hydroxylapatite assay procedure.

Original languageEnglish (US)
Pages (from-to)1257-1263
Number of pages7
JournalChemosphere
Volume18
Issue number1-6
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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