Bioactivity of surface tethered osteogenic growth peptide motifs

Silvia Panseri; Laura Russo; Monica Montesi; Francesca Taraballi; Carla Cunha; Maurilio Marcacci; Laura Cipolla

doi:10.1039/c4md00112e

Bioactivity of surface tethered osteogenic growth peptide motifs

Silvia Panseri, Laura Russo, Monica Montesi, Francesca Taraballi, Carla Cunha, Maurilio Marcacci, Laura Cipolla

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND™ polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications.

Original language	English (US)
Pages (from-to)	899-903
Number of pages	5
Journal	MedChemComm
Volume	5
Issue number	7
DOIs	https://doi.org/10.1039/c4md00112e
State	Published - Jul 2014

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

Access to Document

10.1039/c4md00112e

Cite this

@article{3785b097eafd49a5bade6752e4dfe1b3,

title = "Bioactivity of surface tethered osteogenic growth peptide motifs",

abstract = "Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND{\texttrademark} polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications.",

author = "Silvia Panseri and Laura Russo and Monica Montesi and Francesca Taraballi and Carla Cunha and Maurilio Marcacci and Laura Cipolla",

year = "2014",

month = jul,

doi = "10.1039/c4md00112e",

language = "English (US)",

volume = "5",

pages = "899--903",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Bioactivity of surface tethered osteogenic growth peptide motifs

AU - Panseri, Silvia

AU - Russo, Laura

AU - Montesi, Monica

AU - Taraballi, Francesca

AU - Cunha, Carla

AU - Marcacci, Maurilio

AU - Cipolla, Laura

PY - 2014/7

Y1 - 2014/7

N2 - Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND™ polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications.

AB - Osteogenic Growth Peptide (OGP) motifs were tethered to SULFHYDRYL-BIND™ polystyrene plates tuning spatial presentation of the different functional domains. The effects of the different surface-tethered OGP motifs have been evaluated in mesenchymal stem cells (MSCs) osteogenesis. A culture medium without any osteogenic supplements was used in order to evaluate the OGP effect, avoiding any interference by additional factors. The motif YGFGG resulted to be the most interesting, strongly enhancing the expression of BMP2 that plays a fundamental role in bone regeneration. With this study we present new evidence of the role of OGP in osteogenesis and new insights into different OGP motifs able to act as best ligands for the design of innovative bioactive materials for osteogenesis promotion and regenerative medicine applications.

UR - http://www.scopus.com/inward/record.url?scp=84903313737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903313737&partnerID=8YFLogxK

U2 - 10.1039/c4md00112e

DO - 10.1039/c4md00112e

M3 - Article

AN - SCOPUS:84903313737

SN - 2040-2503

VL - 5

SP - 899

EP - 903

JO - MedChemComm

JF - MedChemComm

IS - 7

ER -

Bioactivity of surface tethered osteogenic growth peptide motifs

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this