Binding of heparin on the surface of cultured human endothelial cells

Bengt Glimelius, Christer Busch, Magnus Höök

    Research output: Contribution to journalArticlepeer-review

    211 Scopus citations

    Abstract

    3H-labelled heparin was shown to bind to the surface of cultured human endothelial cells. The binding was time dependent, saturable, reversible and trypsin sensitive. The binding capacity corresponds to about 106 molecules of heparin per cell. Labelled material released from the cells retained its ability to bind to antithrombin III. Binding of heparin to endothelial cells as well as its release is suggested to be of importance in the pharmacokinetics of heparin and to influence the non-thrombogenic properties of the endothelial lining during heparin therapy.

    Original languageEnglish (US)
    Pages (from-to)773-782
    Number of pages10
    JournalThrombosis Research
    Volume12
    Issue number5
    DOIs
    StatePublished - May 1978

    ASJC Scopus subject areas

    • Hematology

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