Binding and photodynamic action of the cationic zinc phthalocyanines with different types of DNA toward understanding of their cancer therapy activity

Ewan K.S. McRae; Dustin E. Nevonen; Sean A. McKenna; Victor N. Nemykin

doi:10.1016/j.jinorgbio.2019.110793

Binding and photodynamic action of the cationic zinc phthalocyanines with different types of DNA toward understanding of their cancer therapy activity

Ewan K.S. McRae, Dustin E. Nevonen, Sean A. McKenna, Victor N. Nemykin

Houston Methodist

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two cationic zinc phthalocyanines have been tested for their interactions with several DNA secondary structures. Despite different aggregation properties, both phthalocyanines bind to DNA in monomeric forms. The strong photodynamic activity of phthalocyanines was demonstrated by in vitro experiments and correlate well with high singlet oxygen yields determined experimentally with 1,3-diphenylisobenzofurane. Both phthalocyanines accumulate in the cell cytoplasm prior to radiation; however, only the octacationic photosensitizer was observed in the cell nuclei after irradiation.

Original language	English (US)
Article number	110793
Journal	Journal of Inorganic Biochemistry
Volume	199
DOIs	https://doi.org/10.1016/j.jinorgbio.2019.110793
State	Published - Oct 2019

Keywords

Confocal microscopy
DNA binding
Photodynamic therapy
Phthalocyanine
Singlet oxygen generation

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1016/j.jinorgbio.2019.110793

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@article{77ec96c293b34c8f8cdaaf976391184f,

title = "Binding and photodynamic action of the cationic zinc phthalocyanines with different types of DNA toward understanding of their cancer therapy activity",

abstract = "Two cationic zinc phthalocyanines have been tested for their interactions with several DNA secondary structures. Despite different aggregation properties, both phthalocyanines bind to DNA in monomeric forms. The strong photodynamic activity of phthalocyanines was demonstrated by in vitro experiments and correlate well with high singlet oxygen yields determined experimentally with 1,3-diphenylisobenzofurane. Both phthalocyanines accumulate in the cell cytoplasm prior to radiation; however, only the octacationic photosensitizer was observed in the cell nuclei after irradiation.",

keywords = "Confocal microscopy, DNA binding, Photodynamic therapy, Phthalocyanine, Singlet oxygen generation",

author = "McRae, {Ewan K.S.} and Nevonen, {Dustin E.} and McKenna, {Sean A.} and Nemykin, {Victor N.}",

note = "Funding Information: This work was supported by the Minnesota Supercomputing Institute, NSERC, CFI, University of Manitoba, and WestGrid Canada. We also would like to acknowledge Professor Lukyanets for the samples of Pc1 and Pc2. Funding Information: This work was supported by the Minnesota Supercomputing Institute , NSERC , CFI , University of Manitoba , and WestGrid Canada. We also would like to acknowledge Professor Lukyanets for the samples of Pc1 and Pc2 . Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

doi = "10.1016/j.jinorgbio.2019.110793",

language = "English (US)",

volume = "199",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

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T1 - Binding and photodynamic action of the cationic zinc phthalocyanines with different types of DNA toward understanding of their cancer therapy activity

AU - McRae, Ewan K.S.

AU - Nevonen, Dustin E.

AU - McKenna, Sean A.

AU - Nemykin, Victor N.

N1 - Funding Information: This work was supported by the Minnesota Supercomputing Institute, NSERC, CFI, University of Manitoba, and WestGrid Canada. We also would like to acknowledge Professor Lukyanets for the samples of Pc1 and Pc2. Funding Information: This work was supported by the Minnesota Supercomputing Institute , NSERC , CFI , University of Manitoba , and WestGrid Canada. We also would like to acknowledge Professor Lukyanets for the samples of Pc1 and Pc2 . Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/10

Y1 - 2019/10

N2 - Two cationic zinc phthalocyanines have been tested for their interactions with several DNA secondary structures. Despite different aggregation properties, both phthalocyanines bind to DNA in monomeric forms. The strong photodynamic activity of phthalocyanines was demonstrated by in vitro experiments and correlate well with high singlet oxygen yields determined experimentally with 1,3-diphenylisobenzofurane. Both phthalocyanines accumulate in the cell cytoplasm prior to radiation; however, only the octacationic photosensitizer was observed in the cell nuclei after irradiation.

AB - Two cationic zinc phthalocyanines have been tested for their interactions with several DNA secondary structures. Despite different aggregation properties, both phthalocyanines bind to DNA in monomeric forms. The strong photodynamic activity of phthalocyanines was demonstrated by in vitro experiments and correlate well with high singlet oxygen yields determined experimentally with 1,3-diphenylisobenzofurane. Both phthalocyanines accumulate in the cell cytoplasm prior to radiation; however, only the octacationic photosensitizer was observed in the cell nuclei after irradiation.

KW - Confocal microscopy

KW - DNA binding

KW - Photodynamic therapy

KW - Phthalocyanine

KW - Singlet oxygen generation

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JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

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ER -

Binding and photodynamic action of the cationic zinc phthalocyanines with different types of DNA toward understanding of their cancer therapy activity

Abstract

Keywords

ASJC Scopus subject areas

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