Binary function of mRNA

Malgorzata Kloc, Victor Foreman, Sriyutha A. Reddy

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Since the discovery of messenger RNA (mRNA) over half a century ago, the assumption has always been that the only function of mRNA is to make a protein. However, recent studies of prokaryotic and eukaryotic organisms unexpectedly show that some mRNAs may be functionally binary and have additional structural functions that are unrelated to their translation product. These findings imply that some of the phenotypic features of cells and organisms can also be binary, that is, they depend both on the function of a protein and the independent structural function of its mRNA. In this review, we will discuss this concept within the framework of multifunctional RNA molecules and the RNA World Hypothesis.

Original languageEnglish (US)
Pages (from-to)1955-1961
Number of pages7
Issue number11
StatePublished - Nov 2011


  • Cytoskeleton
  • mRNA
  • Multifunctional RNA
  • Nuclear bodies
  • RNA World Hypothesis
  • Structural RNA
  • VegT mRNA

ASJC Scopus subject areas

  • Biochemistry


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