Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy

Tao Yang, Hengte Ke, Qiaoli Wang, Yong'An Tang, Yibin Deng, Hong Yang, Xiangliang Yang, Peng Yang, Daishun Ling, Chunying Chen, Yuliang Zhao, Hong Wu, Huabing Chen

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


Elemental tellurium (Te) nanoparticles are increasingly important in a variety of applications such as thermoelectricity, photoconductivity, and piezoelectricity. However, they have been explored with limited success in their biomedical use, and thus a tremendous challenge still exists in the exploration of Te nanoparticles that can treat tumors as an effective anticancer agent. Here, we introduce bifunctional Te nanodots with well-defined nanostructure as an effective anticancer agent for photo-induced synergistic cancer therapy with tumor ablation, which is accomplished using hollow albumin nanocages as a nanoreactor. Under near-infrared light irradiation, Te nanodots can produce effective photothermal conversion, as well as highly reactive oxygen species such as •O2- and dismutated •OH via a type-I mechanism through direct electron transfer, thereby triggering the potent in vivo hyperthermia and simultaneous intracellular reactive oxygen species at tumors. Moreover, Te nanodots possess perfect resistance to photobleaching, effective cytoplasmic translocation, preferable tumor accumulation, as well as in vivo renal elimination, promoting severe photo-induced cell damage and subsequent synergy between photothermal and photodynamic treatments for tumor ablation. These findings provide the insight of elemental Te nanodots for biomedical research.

Original languageEnglish (US)
Pages (from-to)10012-10024
Number of pages13
JournalACS Nano
Issue number10
StatePublished - Oct 24 2017


  • albumin nanocage
  • photodynamic therapy
  • photothermal therapy
  • tellurium nanodot
  • tumor ablation

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy'. Together they form a unique fingerprint.

Cite this