Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?

Hüseyin Sancar Bozkurt, Eamonn M.M. Quigley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. İmpairment of the gut microbiota has been associated with development of colorectal cancer. The genus Bifidobacterium is an important component of the commensal gut microbiota. Bifidobacteria are considered to have important roles in multiple homeostatic functions: immunologic, hormonal and metabolic. Mucosal-associated invariant T cells (MAIT) are components of the immune system involved in protection against infectious pathogens and regulate the pathogenesis of various inflammatory diseases and, potentially, colorectal cancer. Engagement between Bifidobacterium and MAIT cells could exert a beneficial effect on colorectal cancer prevention and treatment.

Original languageEnglish (US)
Pages (from-to)266-272
Number of pages7
JournalGastrointestinal Disorders
Issue number2
StatePublished - Jun 2019


  • Bifidobacterium
  • MAIT cells
  • colorectal cancer

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Immunology and Microbiology (miscellaneous)
  • Oncology


Dive into the research topics of 'Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention?'. Together they form a unique fingerprint.

Cite this