BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11

Kun Wang; Xiao Ming Yin; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Catherine L. Keck; Drazen B. Zimonjic; Nicholas C. Popescu; Stanley J. Korsmeyer

doi:10.1006/geno.1998.5489

BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11

Kun Wang, Xiao Ming Yin, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Catherine L. Keck, Drazen B. Zimonjic, Nicholas C. Popescu, Stanley J. Korsmeyer

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single α-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene.

Original language	English (US)
Pages (from-to)	235-238
Number of pages	4
Journal	Genomics
Volume	53
Issue number	2
DOIs	https://doi.org/10.1006/geno.1998.5489
State	Published - Oct 15 1998

ASJC Scopus subject areas

Genetics

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10.1006/geno.1998.5489

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@article{ea69dd6cadc242e49099f596618df931,

title = "BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11",

abstract = "BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single α-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene.",

author = "Kun Wang and Yin, {Xiao Ming} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Keck, {Catherine L.} and Zimonjic, {Drazen B.} and Popescu, {Nicholas C.} and Korsmeyer, {Stanley J.}",

note = "Funding Information: We thank Mary Barstead for excellent technical assistance. This research was supported, in part, by RO1 Ca50239 and the National Cancer Institute, DHHS, under contract with ABL. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1998",

month = oct,

day = "15",

doi = "10.1006/geno.1998.5489",

language = "English (US)",

volume = "53",

pages = "235--238",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press",

number = "2",

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TY - JOUR

T1 - BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11

AU - Wang, Kun

AU - Yin, Xiao Ming

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Keck, Catherine L.

AU - Zimonjic, Drazen B.

AU - Popescu, Nicholas C.

AU - Korsmeyer, Stanley J.

N1 - Funding Information: We thank Mary Barstead for excellent technical assistance. This research was supported, in part, by RO1 Ca50239 and the National Cancer Institute, DHHS, under contract with ABL. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1998/10/15

Y1 - 1998/10/15

N2 - BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single α-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene.

AB - BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single α-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene.

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DO - 10.1006/geno.1998.5489

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JO - Genomics

JF - Genomics

SN - 0888-7543

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ER -

BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11

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