Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

Taghreed Almahmeed; Jay O. Boyle; Erik G. Cohen; John F. Carew; Baoheng Du; Nasser K. Altorki; Levy Kopelovich; Jia Long Fang; Philip Lazarus; Kotha Subbaramaiah; Andrew J. Dannenberg

doi:10.1093/carcin/bgh078

Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

Taghreed Almahmeed, Jay O. Boyle, Erik G. Cohen, John F. Carew, Baoheng Du, Nasser K. Altorki, Levy Kopelovich, Jia Long Fang, Philip Lazarus, Kotha Subbaramaiah, Andrew J. Dannenberg

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13 Scopus citations

Abstract

In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

Original language	English (US)
Pages (from-to)	793-799
Number of pages	7
Journal	Carcinogenesis
Volume	25
Issue number	5
DOIs	https://doi.org/10.1093/carcin/bgh078
State	Published - May 2004

ASJC Scopus subject areas

Cancer Research

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Almahmeed, T., Boyle, J. O., Cohen, E. G., Carew, J. F., Du, B., Altorki, N. K., Kopelovich, L., Fang, J. L., Lazarus, P., Subbaramaiah, K., & Dannenberg, A. J. (2004). Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis, 25(5), 793-799. https://doi.org/10.1093/carcin/bgh078

Almahmeed, T, Boyle, JO, Cohen, EG, Carew, JF, Du, B, Altorki, NK, Kopelovich, L, Fang, JL, Lazarus, P, Subbaramaiah, K & Dannenberg, AJ 2004, 'Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract', Carcinogenesis, vol. 25, no. 5, pp. 793-799. https://doi.org/10.1093/carcin/bgh078

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title = "Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract",

abstract = "In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.",

author = "Taghreed Almahmeed and Boyle, \{Jay O.\} and Cohen, \{Erik G.\} and Carew, \{John F.\} and Baoheng Du and Altorki, \{Nasser K.\} and Levy Kopelovich and Fang, \{Jia Long\} and Philip Lazarus and Kotha Subbaramaiah and Dannenberg, \{Andrew J.\}",

note = "Funding Information: This work was supported by NIH grants T32 CA09685 (E.G.C.), R01 CA82578 (A.J.D.), N01-CN-35107 (A.J.D.), R01 DE13158 (P.L.) and P01 CA68384 (P.L., project leader).",

year = "2004",

month = may,

doi = "10.1093/carcin/bgh078",

language = "English (US)",

volume = "25",

pages = "793--799",

journal = "Carcinogenesis",

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T1 - Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

AU - Almahmeed, Taghreed

AU - Boyle, Jay O.

AU - Cohen, Erik G.

AU - Carew, John F.

AU - Du, Baoheng

AU - Altorki, Nasser K.

AU - Kopelovich, Levy

AU - Fang, Jia Long

AU - Lazarus, Philip

AU - Subbaramaiah, Kotha

AU - Dannenberg, Andrew J.

N1 - Funding Information: This work was supported by NIH grants T32 CA09685 (E.G.C.), R01 CA82578 (A.J.D.), N01-CN-35107 (A.J.D.), R01 DE13158 (P.L.) and P01 CA68384 (P.L., project leader).

PY - 2004/5

Y1 - 2004/5

N2 - In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

AB - In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

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Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

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