@article{bdd2e8ed72be4392a9bd0f0d4cb5c5b0,
title = "Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract",
abstract = "In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.",
author = "Taghreed Almahmeed and Boyle, {Jay O.} and Cohen, {Erik G.} and Carew, {John F.} and Baoheng Du and Altorki, {Nasser K.} and Levy Kopelovich and Fang, {Jia Long} and Philip Lazarus and Kotha Subbaramaiah and Dannenberg, {Andrew J.}",
note = "Funding Information: This work was supported by NIH grants T32 CA09685 (E.G.C.), R01 CA82578 (A.J.D.), N01-CN-35107 (A.J.D.), R01 DE13158 (P.L.) and P01 CA68384 (P.L., project leader).",
year = "2004",
month = may,
doi = "10.1093/carcin/bgh078",
language = "English (US)",
volume = "25",
pages = "793--799",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "5",
}