Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

Taghreed Almahmeed, Jay O. Boyle, Erik G. Cohen, John F. Carew, Baoheng Du, Nasser K. Altorki, Levy Kopelovich, Jia Long Fang, Philip Lazarus, Kotha Subbaramaiah, Andrew J. Dannenberg

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12 Scopus citations

Abstract

In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

Original languageEnglish (US)
Pages (from-to)793-799
Number of pages7
JournalCarcinogenesis
Volume25
Issue number5
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Cancer Research

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