Benzo[a]pyrene inhibits protein kinase C activity in subcultured rat aortic smooth muscle cells

Keyphrases

• Protein Kinase 100%
• Benzo(a)pyrene 100%
• Human Aortic Smooth muscle Cells (HASMCs) 100%
• Particulate Matter Components 16%
• Particulate 11%
• Concentration-dependent 11%
• Phosphorylation 11%
• Cytosolic Fraction 11%
• Histone 5%
• P450 5%
• Cell Differentiation 5%
• Inhibitory Effect 5%
• Smooth muscle Cells 5%
• High Concentration 5%
• Cell Growth 5%
• Fetal Bovine Serum 5%
• Cell Wall Proteins 5%
• Protein Synthesis 5%
• Deregulation 5%
• In Vitro Activity 5%
• Biological Basis 5%
• Pyrene Metabolites 5%
• RNA Synthesis 5%
• Enzymatic Activity 5%
• Phorbol 12-myristate 13-acetate 5%
• Protein Phosphorylation 5%
• Cytosolic Proteins 5%
• Time Effect 5%
• Time Course Study 5%
• Oxidative Metabolism 5%
• Subculture 5%
• Parent Compounds 5%
• Inhibitory Response 5%
• Hydroxy Metabolites 5%

Pharmacology, Toxicology and Pharmaceutical Science

• calcium activated,phospholipid dependent protein kinase 100%
• Benzo(a)pyrene 100%
• Cytochrome P450 5%
• Cell Protein 5%
• 12-O-Tetradecanoylphorbol-13-Acetate 5%
• Histone 5%