Behavioral state modulation of auditory activity in a vocal motor system

Amish S. Dave, Albert C. Yu, Daniel Margoliash

Research output: Contribution to journalArticlepeer-review

200 Scopus citations

Abstract

Neurons of the song motor control nucleus robustus archistriatalis (RA) exhibited far weaker auditory responses in awake than in anesthetized zebra finches. Remarkably, sleep induced complex patterns of bursts in ongoing activity and uncovered vigorous auditory responses of RA neurons. Local injections of norepinephrine suggested that the changes in response strength occur through neuromodulatory control of the sensorimotor nucleus HVc, which projects to RA. Thus, motor access to auditory feedback, which zebra finches require for song learning and maintenance, may be regulated through neuromodulation. During sleep, the descending motor system may gain access to sensorimotor song memories represented as bursting patterns of activity.

Original languageEnglish (US)
Pages (from-to)2250-2254
Number of pages5
JournalScience
Volume282
Issue number5397
DOIs
StatePublished - Dec 18 1998

ASJC Scopus subject areas

  • General

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