BDNF Val66Met polymorphism tunes frontolimbic circuitry during affective contextual learning

Mbemba Jabbi, Brett Cropp, Tiffany Nash, Philip Kohn, J. Shane Kippenhan, Joseph C. Masdeu, Raghav Mattay, Bhaskar Kolachana, Karen F. Berman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Adaptive learning impairments are common in cognitive and behavioral disorders, but the neurogenetic mechanisms supporting human affective learning are poorly understood. We designed a higher-order contextual learning task in which healthy participants genotyped for the Val66Met polymorphism of the brain derived neurotropic factor gene (BDNF) were required to choose the member of a picture pair most congruent with the emotion in a previously-viewed facial expression video in order to produce an advantageous monetary outcome. Functional magnetic resonance imaging (fMRI) identified frontolimbic blood oxygenation level dependent (BOLD) reactivity that was associated with BDNF Val66Met genotype during all three phases of the learning task: aversive and reward-predictive learning, contextually-challenging decision-making, and choice-related monetary loss-avoidance and gain outcomes. Relative to Val homozygotes, Met carriers showed attenuated ventromedial prefrontal response to predictive affective cues, dorsolateral prefrontal signaling that depended on decision difficulty, and enhanced ventromedial prefrontal reactivity that was specific to loss-avoidance. These findings indicate that the BDNF Val66Met polymorphism is associated with functional tuning of behaviorally-relevant frontolimbic circuitry, particularly involving the ventromedial prefrontal cortex, during higher-order learning.

Original languageEnglish (US)
Pages (from-to)373-383
Number of pages11
StatePublished - Nov 15 2017

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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