@article{78ee93c2148d4906a4ca06f4a4665b1a,
title = "Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c",
abstract = "During neocortical development, neurons undergo polarization, oriented migration, and layer-type-specific differentiation. The transcriptional programs underlying these processes are not completely understood. Here, we show that the transcription factor Bcl11a regulates polarity and migration of upper layer neurons. Bcl11a-deficient late-born neurons fail to correctly switch from multipolar to bipolar morphology, resulting in impaired radial migration. We show that the expression of Sema3c is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c transcription. Invivo gain-of-function and rescue experiments demonstrate that Sema3c is a major downstream effector of Bcl11a required for the cell polarity switch and for the migration of upper layer neurons. Our data uncover a novel Bcl11a/. Sema3c-dependent regulatory pathway used by migrating cortical neurons. Wiegreffe etal. discover a novel Bcl11a/Sema3c-dependent regulatory pathway that controls polarization and radial migration of late-born upper layer cortical projection neurons. Deletion of Bcl11a in mice ultimately results in severe hypoplasia of upper neocortical layers.",
author = "Christoph Wiegreffe and Ruth Simon and Katharina Peschkes and Carolin Kling and Michael Strehle and Jin Cheng and Swathi Srivatsa and Pentao Liu and Jenkins, {Nancy A.} and Copeland, {Neal G.} and Victor Tarabykin and Stefan Britsch",
note = "Funding Information: We are grateful to C. Cepko (Harvard Medical School, Boston), F. Murakami (Osaka University), A. Nagy (Lunenfeld-Tanenbaum Research Institute, Toronto), K.-A. Nave (Max-Planck-Institute for Experimental Medicine, G{\"o}ttingen), F. Polleux (Scripps Research Institute, La Jolla), and M. Vermeren (Babraham Institute, Cambridge) for the gift of mice and providing DNA plasmids. We thank S. G{\"a}ssler for supporting the project and J. Andratschke, S. Takenaka, E. Werle, and F. Seigfried for excellent technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft (SFB 497/A9 and BR 2215 to S.B.; TA 303/6-1 to V.T.) and Ulm University (Bausteinprogramm 3.2 to C.W.). S.S. was supported by a Boehringer Ingelheim PhD fellowship. N.G.C. and N.A.J. were supported by the Cancer Prevention Research Institute of Texas (CPRIT) and are CPRIT Scholars in Cancer Research. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2015",
month = jul,
day = "15",
doi = "10.1016/j.neuron.2015.06.023",
language = "English (US)",
volume = "87",
pages = "311--325",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}