Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS

Angela Gritti, Lidia Cova, Eugenio A. Parati, Rossella Galli, Angelo Vescovi

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Stem cells isolated from the CNS of both embryonic and adult mice undergo extensive proliferation in the presence of epidermal growth factor (EGF). Removal of EGF determines the differentiation of these cells into neurons and glia. We have recently demonstrated that basic fibroblast growth factor (bFGF) regulates the proliferation of EGF-generated progenitors of the embryonic mouse striatum. We report here that bFGF induces proliferation of some EGF-generated precursors of the adult mouse striatum which, in turn, differentiate in vitro into cells possessing neuron-like morphology and neuronal antigenic properties. These results demonstrate that EGF and bFGF can act sequentially to regulate the de novo generation of neurons from the adult mouse CNS in vitro and suggest the existence of a lineage relationship between EGF- and bFGF-responsive progenitor cells of the adult murine brain.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalNeuroscience Letters
Volume185
Issue number3
DOIs
StatePublished - Feb 13 1995

Keywords

  • Adult central nervous system
  • Adult neuroplasticity
  • Basic fibroblast growth factor
  • Epidermal growth factor
  • Neurogenesis
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)

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