Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries

Monika Colombo, Yong He, Anna Corti, Diego Gallo, Stefano Casarin, Jared M. Rozowsky, Francesco Migliavacca, Scott Berceli, Claudio Chiastra

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


In-stent restenosis (ISR) is the major drawback of superficial femoral artery (SFA) stenting. Abnormal hemodynamics after stent implantation seems to promote the development of ISR. Accordingly, this study aims to investigate the impact of local hemodynamics on lumen remodeling in human stented SFA lesions. Ten SFA models were reconstructed at 1-week and 1-year follow-up from computed tomography images. Patient-specific computational fluid dynamics simulations were performed to relate the local hemodynamics at 1-week, expressed in terms of time-averaged wall shear stress (TAWSS), oscillatory shear index and relative residence time, with the lumen remodeling at 1-year, quantified as the change of lumen area between 1-week and 1-year. The TAWSS was negatively associated with the lumen area change (ρ = − 0.75, p = 0.013). The surface area exposed to low TAWSS was positively correlated with the lumen area change (ρ = 0.69, p = 0.026). No significant correlations were present between the other hemodynamic descriptors and lumen area change. The low TAWSS was the best predictive marker of lumen remodeling (positive predictive value of 44.8%). Moreover, stent length and overlapping were predictor of ISR at follow-up. Despite the limited number of analyzed lesions, the overall findings suggest an association between abnormal patterns of WSS after stenting and lumen remodeling.

Original languageEnglish (US)
Article number1613
Pages (from-to)1613
JournalScientific Reports
Issue number1
StatePublished - Jan 15 2021


  • Aged
  • Atrial Remodeling
  • Computer Simulation
  • Constriction, Pathologic/surgery
  • Femoral Artery/diagnostic imaging
  • Follow-Up Studies
  • Hemodynamics
  • Humans
  • Logistic Models
  • Middle Aged
  • Peripheral Arterial Disease/surgery
  • Shear Strength
  • Spatial Analysis
  • Stents/adverse effects
  • Time Factors
  • Tomography, X-Ray Computed

ASJC Scopus subject areas

  • General


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