TY - JOUR
T1 - Basal cell carcinoma treated with Mohs micrographic surgery in young Ibero-American patients
AU - Aluma-Tenorio, María Soledad
AU - Ávila-Álvarez, Alejandra
AU - Jaimes, Natalia
AU - Caballero-Uribe, Natalia
AU - González, Abel
AU - Terzian, Luiz Roberto
AU - Ocampo-Candiani, Jorge
AU - Zuluaga, María Alejandra
AU - Garza-Rodríguez, Verónica
AU - Tamayo-Betancur, María Carolina
AU - Cuesta- Castro, Diana Paola
AU - Garcés, Joan Ramón
AU - Ruiz-Salas, Verónica
AU - Goldberg, Leonard
AU - Kimyai-Asadi, Arash
N1 - © 2018 The International Society of Dermatology.
PY - 2018/12
Y1 - 2018/12
N2 - Background: The incidence of basal cell carcinoma (BCC) in younger individuals has increased in recent decades. However, the characteristics of BCCs in this population, especially in Ibero-Latin American countries, have not been completely defined. Objective: To describe the demographic, clinical, and histopathological characteristics of BCCs in patients younger than 40 treated with Mohs Micrographic Surgery (MMS). Materials and Methods: A multicenter, retrospective study conducted between January 2009 and December 2014, in five Ibero-American countries, included biopsy-proven BCCs in patients younger than 40 that were treated with MMS. Demographic, clinical, histopathological, and surgical characteristics were described. Results: The study included 301 tumors in 241 patients, of whom 61% were female. The most common Fitzpatrick phototype was III. The most common histological subtypes were nodular (37.5%) and infiltrative (18.9%). Perineural invasion was encountered in 1.7%, and tumor clearance was achieved in 87.4% within two stages of MMS. Conclusions: This is the first Ibero-Latin American transnational study describing the characteristics of BCCs in young patients treated with MMS. Despite darker skin phototypes in this population, BCCs can occur in early ages and may present with aggressive features. Therefore, MMS may be considered an appropriate first-line treatment option in this population.
AB - Background: The incidence of basal cell carcinoma (BCC) in younger individuals has increased in recent decades. However, the characteristics of BCCs in this population, especially in Ibero-Latin American countries, have not been completely defined. Objective: To describe the demographic, clinical, and histopathological characteristics of BCCs in patients younger than 40 treated with Mohs Micrographic Surgery (MMS). Materials and Methods: A multicenter, retrospective study conducted between January 2009 and December 2014, in five Ibero-American countries, included biopsy-proven BCCs in patients younger than 40 that were treated with MMS. Demographic, clinical, histopathological, and surgical characteristics were described. Results: The study included 301 tumors in 241 patients, of whom 61% were female. The most common Fitzpatrick phototype was III. The most common histological subtypes were nodular (37.5%) and infiltrative (18.9%). Perineural invasion was encountered in 1.7%, and tumor clearance was achieved in 87.4% within two stages of MMS. Conclusions: This is the first Ibero-Latin American transnational study describing the characteristics of BCCs in young patients treated with MMS. Despite darker skin phototypes in this population, BCCs can occur in early ages and may present with aggressive features. Therefore, MMS may be considered an appropriate first-line treatment option in this population.
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U2 - 10.1111/ijd.14195
DO - 10.1111/ijd.14195
M3 - Article
C2 - 30168850
AN - SCOPUS:85052902769
SN - 0011-9059
VL - 57
SP - 1447
EP - 1453
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 12
ER -