Bacteriophage-antibiotic combinations for enterococcus faecium with varying bacteriophage and daptomycin susceptibilities

Taylor Morrisette, Katherine L. Lev, Razieh Kebriaei, Jacinda C. Abdul-Mutakabbir, Kyle C. Stamper, Sandra Morales, Susan M. Lehman, Gregory S. Canfield, Breck A. Duerkop, Cesar A. Arias, Michael J. Rybak

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium. After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.

Original languageEnglish (US)
Article numbere00993-20
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • Bacteriophage-antibiotic combinations
  • Bacteriophages
  • Daptomycin
  • Enterococcus faecium

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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