Bacterial cell membranes and their role in daptomycin resistance: A review

April H. Nguyen, Kara Hood, Eugenia Mileykovskaya, William R. Miller, Cecilia Tran

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Lipids play a major role in bacterial cells. Foremost, lipids are the primary constituents of the cell membrane bilayer, providing structure and separating the cell from the surrounding environment. This makes the lipid bilayer a prime target for antimicrobial peptides and membrane-acting antibiotics such as daptomycin. In response, bacteria have evolved mechanisms by which the membrane can be adapted to resist attack by these antimicrobial compounds. In this review, we focus on the membrane phospholipid changes associated with daptomycin resistance in enterococci, Staphylococcus aureus, and the Viridans group streptococci.
Original languageEnglish (US)
Article number1035574
Pages (from-to)1035574
JournalFrontiers in Molecular Biosciences
StatePublished - Nov 14 2022


  • Staphylococcus aureus
  • daptomycin
  • enterococci
  • phospholipids
  • resistance
  • streptococci

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)


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