Bacterial cancer therapy: A turning point for new paradigms

Vijayakumar Mayakrishnan; Priya Kannappan; Nagendran Tharmalingam; Rajendran J.C. Bose; Thiagarajan Madheswaran; Mohankandhasamy Ramasamy

doi:10.1016/j.drudis.2022.03.007

Bacterial cancer therapy: A turning point for new paradigms

Vijayakumar Mayakrishnan, Priya Kannappan, Nagendran Tharmalingam, Rajendran J.C. Bose, Thiagarajan Madheswaran, Mohankandhasamy Ramasamy

Houston Methodist

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Cancer treatments have advanced considerably in recent years, appreciably enhancing the quality of life and survival of cancer patients. However, standard cancer treatments still have limitations that must be improved. In recent years, bacteria-based cancer therapy has gained much more attention owing to its unique properties that are unachievable with standard therapeutics. Bacteria species such as Salmonella, Clostridium, and Listeria have been shown to control tumor growth with improved prognosis in experimental animal models and clinical settings.

Original language	English (US)
Pages (from-to)	2043-2050
Number of pages	8
Journal	Drug Discovery Today
Volume	27
Issue number	8
DOIs	https://doi.org/10.1016/j.drudis.2022.03.007
State	Published - Aug 2022

Keywords

Anticancer
Bacterial-mediated
Engineered bacteria
Payload delivery
Tumor microenvironment
Tumor targeting

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.drudis.2022.03.007

Cite this

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title = "Bacterial cancer therapy: A turning point for new paradigms",

abstract = "Cancer treatments have advanced considerably in recent years, appreciably enhancing the quality of life and survival of cancer patients. However, standard cancer treatments still have limitations that must be improved. In recent years, bacteria-based cancer therapy has gained much more attention owing to its unique properties that are unachievable with standard therapeutics. Bacteria species such as Salmonella, Clostridium, and Listeria have been shown to control tumor growth with improved prognosis in experimental animal models and clinical settings.",

keywords = "Anticancer, Bacterial-mediated, Engineered bacteria, Payload delivery, Tumor microenvironment, Tumor targeting",

author = "Vijayakumar Mayakrishnan and Priya Kannappan and Nagendran Tharmalingam and Bose, \{Rajendran J.C.\} and Thiagarajan Madheswaran and Mohankandhasamy Ramasamy",

note = "Funding Information: The authors would like to acknowledge Masonic Medical Research Institute, Utica, New York, the USA for the 2021 Halfond-Weil Postdoctoral Award, and the University of Waterloo, Canada, for extending support. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = aug,

doi = "10.1016/j.drudis.2022.03.007",

language = "English (US)",

volume = "27",

pages = "2043--2050",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Bacterial cancer therapy

T2 - A turning point for new paradigms

AU - Mayakrishnan, Vijayakumar

AU - Kannappan, Priya

AU - Tharmalingam, Nagendran

AU - Bose, Rajendran J.C.

AU - Madheswaran, Thiagarajan

AU - Ramasamy, Mohankandhasamy

N1 - Funding Information: The authors would like to acknowledge Masonic Medical Research Institute, Utica, New York, the USA for the 2021 Halfond-Weil Postdoctoral Award, and the University of Waterloo, Canada, for extending support. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/8

Y1 - 2022/8

N2 - Cancer treatments have advanced considerably in recent years, appreciably enhancing the quality of life and survival of cancer patients. However, standard cancer treatments still have limitations that must be improved. In recent years, bacteria-based cancer therapy has gained much more attention owing to its unique properties that are unachievable with standard therapeutics. Bacteria species such as Salmonella, Clostridium, and Listeria have been shown to control tumor growth with improved prognosis in experimental animal models and clinical settings.

AB - Cancer treatments have advanced considerably in recent years, appreciably enhancing the quality of life and survival of cancer patients. However, standard cancer treatments still have limitations that must be improved. In recent years, bacteria-based cancer therapy has gained much more attention owing to its unique properties that are unachievable with standard therapeutics. Bacteria species such as Salmonella, Clostridium, and Listeria have been shown to control tumor growth with improved prognosis in experimental animal models and clinical settings.

KW - Anticancer

KW - Bacterial-mediated

KW - Engineered bacteria

KW - Payload delivery

KW - Tumor microenvironment

KW - Tumor targeting

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U2 - 10.1016/j.drudis.2022.03.007

DO - 10.1016/j.drudis.2022.03.007

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SN - 1359-6446

VL - 27

SP - 2043

EP - 2050

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

Bacterial cancer therapy: A turning point for new paradigms

Abstract

Keywords

ASJC Scopus subject areas

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