Bacterial adherence to pharyngeal cells during viral infection

Victor Fainstein; D. M. Musher; T. R. Cate

doi:10.1093/infdis/141.2.172

Bacterial adherence to pharyngeal cells during viral infection

Victor Fainstein, D. M. Musher, T. R. Cate

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

Adherence of bacteria to pharyngeal cells from patients with naturally acquired acute respiratory illness and from volunteers experimentally infected with influenza virus vaccine was studied. Increased adherence of Staphylococcus aureus was found in both groups. In addition, Haemophilus influenzae and Streptococcus pneumoniae type I adhered in increased numbers to cells from volunteers experimentally infected with influenza virus. Alterations in mucosal cells leading to increased bacterial adherence may play a role in the pathogenesis of suprainfection by these organisms in patients with viral respiratory diseases.

Original language	English (US)
Pages (from-to)	172-176
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	141
Issue number	2
DOIs	https://doi.org/10.1093/infdis/141.2.172
State	Published - 1980

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/141.2.172

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title = "Bacterial adherence to pharyngeal cells during viral infection",

abstract = "Adherence of bacteria to pharyngeal cells from patients with naturally acquired acute respiratory illness and from volunteers experimentally infected with influenza virus vaccine was studied. Increased adherence of Staphylococcus aureus was found in both groups. In addition, Haemophilus influenzae and Streptococcus pneumoniae type I adhered in increased numbers to cells from volunteers experimentally infected with influenza virus. Alterations in mucosal cells leading to increased bacterial adherence may play a role in the pathogenesis of suprainfection by these organisms in patients with viral respiratory diseases.",

author = "Victor Fainstein and Musher, \{D. M.\} and Cate, \{T. R.\}",

note = "Funding Information: Received for publication May 1, 1979, and in revised form September 5. 1979. This study was supported by research funds from the Veterans Administration and by contract no. AI 92611 and grant no. RR 00350 from the National Institutes of Health. We thank the personnel of the Baylor Clinical Research Center for participation in viral vaccine studies. Dr. J. Thornby, Chief, Biostatistics Laboratory, Houston Veterans Administration Medical Center, for statistical analyses. and Mrs. Mona Thomas for secretarial assistance. Please address requests for reprints to Dr. Daniel M. Musher, Infectious Diseases Section, Veterans Administration Medical Center. Houston, Texas 77211. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1980",

doi = "10.1093/infdis/141.2.172",

language = "English (US)",

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journal = "Journal of Infectious Diseases",

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AU - Musher, D. M.

AU - Cate, T. R.

N1 - Funding Information: Received for publication May 1, 1979, and in revised form September 5. 1979. This study was supported by research funds from the Veterans Administration and by contract no. AI 92611 and grant no. RR 00350 from the National Institutes of Health. We thank the personnel of the Baylor Clinical Research Center for participation in viral vaccine studies. Dr. J. Thornby, Chief, Biostatistics Laboratory, Houston Veterans Administration Medical Center, for statistical analyses. and Mrs. Mona Thomas for secretarial assistance. Please address requests for reprints to Dr. Daniel M. Musher, Infectious Diseases Section, Veterans Administration Medical Center. Houston, Texas 77211. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1980

Y1 - 1980

N2 - Adherence of bacteria to pharyngeal cells from patients with naturally acquired acute respiratory illness and from volunteers experimentally infected with influenza virus vaccine was studied. Increased adherence of Staphylococcus aureus was found in both groups. In addition, Haemophilus influenzae and Streptococcus pneumoniae type I adhered in increased numbers to cells from volunteers experimentally infected with influenza virus. Alterations in mucosal cells leading to increased bacterial adherence may play a role in the pathogenesis of suprainfection by these organisms in patients with viral respiratory diseases.

AB - Adherence of bacteria to pharyngeal cells from patients with naturally acquired acute respiratory illness and from volunteers experimentally infected with influenza virus vaccine was studied. Increased adherence of Staphylococcus aureus was found in both groups. In addition, Haemophilus influenzae and Streptococcus pneumoniae type I adhered in increased numbers to cells from volunteers experimentally infected with influenza virus. Alterations in mucosal cells leading to increased bacterial adherence may play a role in the pathogenesis of suprainfection by these organisms in patients with viral respiratory diseases.

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Bacterial adherence to pharyngeal cells during viral infection

Abstract

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