Bacteria: A New Player in Gastrointestinal Motility Disorders-Infections, Bacterial Overgrowth, and Probiotics

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Irritable bowel syndrome (IBS) may result from a dysfunctional interaction between the indigenous flora and the intestinal mucosa, which in turn leads to immune activation in the colonic mucosa. Some propose that bacterial overgrowth is a common causative factor in the pathogenesis of symptoms in IBS; others point to evidence suggesting that the cause stems from more subtle qualitative changes in the colonic flora. Bacterial overgrowth will probably prove not to be a major factor in what will eventually be defined as IBS. Nevertheless, short-term therapy with either antibiotics or probiotics seems to reduce symptoms among IBS patients. However, in the long term, safety issues will favor the probiotic approach; results of long-term studies with these agents are eagerly awaited.

Original languageEnglish (US)
Pages (from-to)735-748
Number of pages14
JournalGastroenterology Clinics of North America
Volume36
Issue number3
DOIs
StatePublished - Sep 1 2007

ASJC Scopus subject areas

  • Gastroenterology

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