Abstract

The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, in the setting of organ transplantation, is dependent on this B-cell response, which does not appear to be halted by current immunosuppressive regimens which are targeted at T cells. There is emerging evidence that shows that B cells have a diverse response to solid organ transplantation that extends beyond plasma cell antibody production. In this review, we discuss the mechanistic pathways of B-cell activation and differentiation as they relate to the transcriptional regulation of germinal center B cells, plasma cells, and memory B cells in the setting of solid organ transplantation.

Original languageEnglish (US)
Article number895157
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Aug 9 2022

Keywords

  • B cells
  • alloimmunity
  • rejection
  • transcriptional (regulation)
  • transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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