AZGP-1 immunohistochemical marker in prostate cancer: Potential predictive marker of biochemical recurrence in post radical prostatectomy specimens

Woon Yong Jung, Chang Ohk Sung, Sang Hak Han, Kyungeun Kim, Misung Kim, Jae Y. Ro, Mun Jung Kang, Hanjong Ahn, Yong Mee Cho

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

One of the major challenges in prostate cancer research is to identify prognostic/predictive factors to distinguish aggressive disease from indolent one. To select prognostic/predictive markers of postoperative biochemical recurrence (BCR) that could be easily performed in daily pathology practice, the expression of 6 immunohistochemical markers including zinc-a-2-glycoprotein (AZGP-1), hCAP-D3, mucin 1, vimentin, E-cadherin, and ERG was assessed in a tissue microarray of 400 radical prostatectomy specimens. The expression levels were correlated with clinicopathologic factors and BCR. During the median follow-up period of 55 months, BCR occurred in 70 cases (17.5%). Low expression of AZGP-1 was noted in 76 cases (19.0%), whereas high expression of hCAP-D3, mucin 1, vimentin, and ERG was observed in 205 (51.3%), 81 (20.3%), 33 (8.3%), and 58 (14.5%) cases, respectively. Aberrant E-cadherin expression was noted in 29 cases (7.3%). By univariate analysis, BCR was associated with low expression of AZGP-1, high expression of hCAP-D3, and aberrant expression of E-cadherin. By multivariate analysis, only AZGP-1 remained an independent immunohistochemical factor, in addition to age, preoperative serum prostate-specific antigen level, Gleason score, tumor stage, and resection margin status. These results show that AZGP-1, hCAP-D3, and E-cadherin are potentially useful immunohistochemical markers to predict BCR, and that AZGP-1 can be used as an independent prognostic marker of aggressive prostate cancer.

Original languageEnglish (US)
Pages (from-to)652-657
Number of pages6
JournalApplied Immunohistochemistry and Molecular Morphology
Volume22
Issue number9
DOIs
StatePublished - 2014

Keywords

  • AZGP-1
  • E-cadherin
  • HCAP-D3
  • Prostate cancer
  • Recurrence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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