Autophagy in pulmonary diseases

Kiichi Nakahira, Maria Angelica Pabon Porras, Augustine M.K. Choi

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The pathogenesis of pulmonary diseases is often complex and characterized by multiple cellular events, including inflammation, cell death, and cell proliferation. The mechanisms by which these events are regulated in pulmonary diseases remain poorly understood. Autophagy is an essential process for cellular homeostasis and stress adaptation in eukaryotic cells. This highly conserved cellular process involves the sequestration of cytoplasmic components in double-membrane autophagosomes, which are delivered to lysosomes for degradation. The critical roles of autophagy have been demonstrated in a wide range of pathophysiological conditions. Emerging studies have identified that autophagy plays important roles in the pathogenesis of various lung diseases. In addition, autophagy has been shown to selectively degrade subcellular targets, including proteins, organelles, and pathogens. Here, we highlight the recent advances in the molecular regulation and function of autophagy in lung diseases.

Original languageEnglish (US)
Pages (from-to)1196-1207
Number of pages12
JournalAmerican journal of respiratory and critical care medicine
Volume194
Issue number10
DOIs
StatePublished - Nov 15 2016

Keywords

  • Autophagy
  • Mitochondria
  • Pulmonary diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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