Autophagy in neurodegenerative diseases: pathogenesis and therapy

Fang Guo, Xinyao Liu, Huaibin Cai, Weidong Le

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations

Abstract

The most prevalent pathological features of many neurodegenerative diseases are the aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy, as major intracellular machinery for degrading aggregated proteins and damaged organelles, has been reported to be involved in the occurrence of pathological changes in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. In this review, we summarize most recent research progress in this topic and provide a new perspective regarding autophagy regulation on the pathogenesis of neurodegenerative diseases. Finally, we discuss the signaling molecules in autophagy-related pathways as therapeutic targets for the treatment of these diseases.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalBrain Pathology
Volume28
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • autophagy
  • neurodegenerative diseases
  • protein aggregation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

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