Autophagy in major human diseases

Daniel J. Klionsky; Giulia Petroni; Ravi K. Amaravadi; Eric H. Baehrecke; Andrea Ballabio; Patricia Boya; José Manuel Bravo-San Pedro; Ken Cadwell; Francesco Cecconi; Augustine M.K. Choi; Mary E. Choi; Charleen T. Chu; Patrice Codogno; Maria Isabel Colombo; Ana Maria Cuervo; Vojo Deretic; Ivan Dikic; Zvulun Elazar; Eeva Liisa Eskelinen; Gian Maria Fimia; David A. Gewirtz; Douglas R. Green; Malene Hansen; Marja Jäättelä; Terje Johansen; Gábor Juhász; Vassiliki Karantza; Claudine Kraft; Guido Kroemer; Nicholas T. Ktistakis; Sharad Kumar; Carlos Lopez-Otin; Kay F. Macleod; Frank Madeo; Jennifer Martinez; Alicia Meléndez; Noboru Mizushima; Christian Münz; Josef M. Penninger; Rushika M Perera; Mauro Piacentini; Fulvio Reggiori; David C. Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Laura Santambrogio; Luca Scorrano; Hans Uwe Simon; Anna Katharina Simon; Anne Simonsen; Alexandra Stolz; Nektarios Tavernarakis; Sharon A. Tooze; Tamotsu Yoshimori; Junying Yuan; Zhenyu Yue; Qing Zhong; Lorenzo Galluzzi; Federico Pietrocola

doi:10.15252/embj.2021108863

Autophagy in major human diseases

Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M.K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva Liisa Eskelinen, Gian Maria FimiaDavid A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef M. Penninger, Rushika M Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola

Research output: Contribution to journal › Review article › peer-review

734 Scopus citations

Abstract

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Original language	English (US)
Article number	e108863
Journal	EMBO Journal
Volume	40
Issue number	19
DOIs	https://doi.org/10.15252/embj.2021108863
State	Published - Oct 1 2021

Keywords

aging
cancer
inflammation
metabolic syndromes
neurodegeneration

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.15252/embj.2021108863

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Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo-San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., Choi, M. E., Chu, C. T., Codogno, P., Colombo, MI., Cuervo, A. M., Deretic, V., Dikic, I., Elazar, Z., Eskelinen, E. L., ... Pietrocola, F. (2021). Autophagy in major human diseases. EMBO Journal, 40(19), Article e108863. https://doi.org/10.15252/embj.2021108863

Klionsky, DJ, Petroni, G, Amaravadi, RK, Baehrecke, EH, Ballabio, A, Boya, P, Bravo-San Pedro, JM, Cadwell, K, Cecconi, F, Choi, AMK, Choi, ME, Chu, CT, Codogno, P, Colombo, MI, Cuervo, AM, Deretic, V, Dikic, I, Elazar, Z, Eskelinen, EL, Fimia, GM, Gewirtz, DA, Green, DR, Hansen, M, Jäättelä, M, Johansen, T, Juhász, G, Karantza, V, Kraft, C, Kroemer, G, Ktistakis, NT, Kumar, S, Lopez-Otin, C, Macleod, KF, Madeo, F, Martinez, J, Meléndez, A, Mizushima, N, Münz, C, Penninger, JM, Perera, RM, Piacentini, M, Reggiori, F, Rubinsztein, DC, Ryan, KM, Sadoshima, J, Santambrogio, L, Scorrano, L, Simon, HU, Simon, AK, Simonsen, A, Stolz, A, Tavernarakis, N, Tooze, SA, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q, Galluzzi, L & Pietrocola, F 2021, 'Autophagy in major human diseases', EMBO Journal, vol. 40, no. 19, e108863. https://doi.org/10.15252/embj.2021108863

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abstract = "Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.",

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AU - Klionsky, Daniel J.

AU - Petroni, Giulia

AU - Amaravadi, Ravi K.

AU - Baehrecke, Eric H.

AU - Ballabio, Andrea

AU - Boya, Patricia

AU - Bravo-San Pedro, José Manuel

AU - Cadwell, Ken

AU - Cecconi, Francesco

AU - Choi, Augustine M.K.

AU - Choi, Mary E.

AU - Chu, Charleen T.

AU - Codogno, Patrice

AU - Colombo, Maria Isabel

AU - Cuervo, Ana Maria

AU - Deretic, Vojo

AU - Dikic, Ivan

AU - Elazar, Zvulun

AU - Eskelinen, Eeva Liisa

AU - Fimia, Gian Maria

AU - Gewirtz, David A.

AU - Green, Douglas R.

AU - Hansen, Malene

AU - Jäättelä, Marja

AU - Johansen, Terje

AU - Juhász, Gábor

AU - Karantza, Vassiliki

AU - Kraft, Claudine

AU - Kroemer, Guido

AU - Ktistakis, Nicholas T.

AU - Kumar, Sharad

AU - Lopez-Otin, Carlos

AU - Macleod, Kay F.

AU - Madeo, Frank

AU - Martinez, Jennifer

AU - Meléndez, Alicia

AU - Mizushima, Noboru

AU - Münz, Christian

AU - Penninger, Josef M.

AU - Perera, Rushika M

AU - Piacentini, Mauro

AU - Reggiori, Fulvio

AU - Rubinsztein, David C.

AU - Ryan, Kevin M

AU - Sadoshima, Junichi

AU - Santambrogio, Laura

AU - Scorrano, Luca

AU - Simon, Hans Uwe

AU - Simon, Anna Katharina

AU - Simonsen, Anne

AU - Stolz, Alexandra

AU - Tavernarakis, Nektarios

AU - Tooze, Sharon A.

AU - Yoshimori, Tamotsu

AU - Yuan, Junying

AU - Yue, Zhenyu

AU - Zhong, Qing

AU - Galluzzi, Lorenzo

AU - Pietrocola, Federico

PY - 2021/10/1

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N2 - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

AB - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

KW - aging

KW - cancer

KW - inflammation

KW - metabolic syndromes

KW - neurodegeneration

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DO - 10.15252/embj.2021108863

M3 - Review article

C2 - 34459017

AN - SCOPUS:85113807620

SN - 0261-4189

VL - 40

JO - EMBO Journal

JF - EMBO Journal

IS - 19

M1 - e108863

ER -

Autophagy in major human diseases

Abstract

Keywords

ASJC Scopus subject areas

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