Autophagy in chronic lung disease

Alexandra C. Racanelli, Augustine M.K. Choi, Mary E. Choi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory and protective/barrier functions necessary to manage the chronic exposures to environmental, mechanical, and oxidative stressors. Autophagy is essential to lung development and homeostasis, as well as the prevention and development of disease. The cellular process involves the collection and removal of unwanted organelles and proteins through lysosomal degradation. In recent years, investigations have addressed the roles of autophagy and selective autophagy in numerous chronic lung diseases. Here, we highlight recent advances on the role of autophagy in the pathogenesis of asthma, chronic obstructive pulmonary disease and emphysema, pulmonary arterial hypertension, and idiopathic pulmonary fibrosis.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
EditorsAitziber Buqué Martinez, Lorenzo Galluzzi
PublisherElsevier B.V.
Pages135-156
Number of pages22
ISBN (Print)9780128220214
DOIs
StatePublished - 2020

Publication series

NameProgress in Molecular Biology and Translational Science
Volume172
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Asthma
  • Autophagy
  • COPD
  • Emphysema
  • Idiopathic pulmonary fibrosis
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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