Autophagy: Cellular defense to excessive inflammation

Eun Kyeong Jo; Dong Min Shin; Augustine M.K. Choi

doi:10.1016/j.micinf.2011.08.014

Autophagy: Cellular defense to excessive inflammation

Eun Kyeong Jo, Dong Min Shin, Augustine M.K. Choi

Research output: Contribution to journal › Short survey

25 Scopus citations

Abstract

Autophagy can orchestrate a variety of cellular responses to dangerous stimuli. Our understanding of the physiologic roles of autophagy has recently expanded; in addition to its other roles, autophagy now appears to play an essential role in regulating inflammatory responses. This review describes recent findings concerning the roles and mechanisms of autophagy in controlling excessive inflammation.

Original language	English (US)
Pages (from-to)	119-125
Number of pages	7
Journal	Microbes and Infection
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.micinf.2011.08.014
State	Published - Feb 2012

Keywords

Autophagy
Autophagy-related genes
Cargo receptors
Inflammasome
Inflammation
Pattern recognition receptors

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2011.08.014

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abstract = "Autophagy can orchestrate a variety of cellular responses to dangerous stimuli. Our understanding of the physiologic roles of autophagy has recently expanded; in addition to its other roles, autophagy now appears to play an essential role in regulating inflammatory responses. This review describes recent findings concerning the roles and mechanisms of autophagy in controlling excessive inflammation.",

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AU - Choi, Augustine M.K.

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KW - Cargo receptors

KW - Inflammasome

KW - Inflammation

KW - Pattern recognition receptors

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