TY - JOUR
T1 - Autophagy and inflammation in chronic respiratory disease
AU - Racanelli, Alexandra C.
AU - Kikkers, Sarah Ann
AU - Choi, Augustine M.K.
AU - Cloonan, Suzanne M.
N1 - Funding Information:
This work was supported by the American Lung Association of the North-east [grant number RG-348928]; HHS j NIH j National Heart, Lung, and Blood Institute (NHBLI) [grant number P01-HL114501], [grant number R01-HL079904], [grant number P01-HL105339], [grant number K99-HL125899], [grant number R01-HL055330].
Funding Information:
This work was supported by the US National Institute of Health–National Heart, Lung and Blood Institute; K99-HL125899 (S.M.C.), P01-HL114501 (A.M.K.C.), R01-HL055330 (A.M.K.C.), R01-HL079904 (A.M.K.C.) and P01-HL105339 (to Edwin K. Silverman) and by an American Lung Association Biomedical Research grant RG-348928 (S.M.C.).
Funding Information:
This work was supported by the American Lung Association of the Northeast [grant number RG-348928]; HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) [grant number P01-HL114501], [grant number R01-HL079904], [grant number P01-HL105339], [grant number K99-HL125899], [grant number R01-HL055330]. This work was supported by the US National Institute of Health–National Heart, Lung and Blood Institute; K99-HL125899 (S.M.C.), P01-HL114501 (A.M.K.C.), R01-HL055330 (A.M.K.C.), R01-HL079904 (A.M.K.C.) and P01-HL105339 (to Edwin K. Silverman) and by an American Lung Association Biomedical Research grant RG-348928 (S.M.C.).
Publisher Copyright:
© 2017 Taylor and Francis Group, LLC.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. Chronic inflammation in the lung may arise from a combination of genetic susceptibility and environmental influences, including exposure to microbes, particles from the atmosphere, irritants, pollutants, allergens, and toxic molecules. To this end, an immediate, strong, and highly regulated inflammatory defense mechanism is needed for the successful maintenance of homeostasis within the respiratory system. Macroautophagy/autophagy plays an essential role in the inflammatory response of the lung to infection and stress. At baseline, autophagy may be critical for inhibiting spontaneous pulmonary inflammation and fundamental for the response of pulmonary leukocytes to infection; however, when not regulated, persistent or inefficient autophagy may be detrimental to lung epithelial cells, promoting lung injury. This perspective will discuss the role of autophagy in driving and regulating inflammatory responses of the lung in chronic lung diseases with a focus on potential avenues for therapeutic targeting. AbbreviationsAR allergic rhinitisAM alveolar macrophageATG autophagy-relatedCF cystic fibrosisCFTR cystic fibrosis transmembrane conductance regulatorCOPD chronic obstructive pulmonary diseaseCS cigarette smokeCSE cigarette smoke extractDC dendritic cellIH intermittent hypoxiaIPF idiopathic pulmonary fibrosisILD interstitial lung diseaseMAP1LC3B microtubule associated protein 1 light chain 3 betaMTBMycobacterium tuberculosisMTOR mechanistic target of rapamycin kinaseNET neutrophil extracellular trapsOSA obstructive sleep apneaPAH pulmonary arterial hypertensionPH pulmonary hypertensionROS reactive oxygen speciesTGFB1 transforming growth factor beta 1TNF tumor necrosis factor.
AB - Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. Chronic inflammation in the lung may arise from a combination of genetic susceptibility and environmental influences, including exposure to microbes, particles from the atmosphere, irritants, pollutants, allergens, and toxic molecules. To this end, an immediate, strong, and highly regulated inflammatory defense mechanism is needed for the successful maintenance of homeostasis within the respiratory system. Macroautophagy/autophagy plays an essential role in the inflammatory response of the lung to infection and stress. At baseline, autophagy may be critical for inhibiting spontaneous pulmonary inflammation and fundamental for the response of pulmonary leukocytes to infection; however, when not regulated, persistent or inefficient autophagy may be detrimental to lung epithelial cells, promoting lung injury. This perspective will discuss the role of autophagy in driving and regulating inflammatory responses of the lung in chronic lung diseases with a focus on potential avenues for therapeutic targeting. AbbreviationsAR allergic rhinitisAM alveolar macrophageATG autophagy-relatedCF cystic fibrosisCFTR cystic fibrosis transmembrane conductance regulatorCOPD chronic obstructive pulmonary diseaseCS cigarette smokeCSE cigarette smoke extractDC dendritic cellIH intermittent hypoxiaIPF idiopathic pulmonary fibrosisILD interstitial lung diseaseMAP1LC3B microtubule associated protein 1 light chain 3 betaMTBMycobacterium tuberculosisMTOR mechanistic target of rapamycin kinaseNET neutrophil extracellular trapsOSA obstructive sleep apneaPAH pulmonary arterial hypertensionPH pulmonary hypertensionROS reactive oxygen speciesTGFB1 transforming growth factor beta 1TNF tumor necrosis factor.
KW - asthma
KW - autophagy
KW - chronic obstructive pulmonary disease (COPD)
KW - inflammation
KW - pulmonary fibrosis
KW - pulmonary hypertension
KW - sleep apnea
KW - tuberculosis
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U2 - 10.1080/15548627.2017.1389823
DO - 10.1080/15548627.2017.1389823
M3 - Review article
C2 - 29130366
AN - SCOPUS:85045253330
SN - 1554-8627
VL - 14
SP - 221
EP - 232
JO - Autophagy
JF - Autophagy
IS - 2
ER -