Autophagic flux and oxidative capacity of skeletal muscles during acute starvation

Mahroo Mofarrahi, Yeting Guo, Jeffrey A. Haspel, Augustine M K Choi , Elaine C. Davis, Gilles Gouspillou, Russell T. Hepple, Richard Godin, Yan Burelle, Sabah N.A. Hussain

Research output: Contribution to journalArticle

33 Scopus citations


ACTB, actin, beta; AKT, v-akt murine thymoma viral oncogene homolog; AMPK, 5'AMP-activated protein kinase; ANOVA, analysis of variance; ATG4B, autophagy-related 4B, cysteine peptidase; ATG5, autophagy-related 5; ATG7, autophagy-related 7; ATG12, autophagy-related 12; ATG13, autophagy-related 13; ATG14, autophagy-related 14; BCL2/ PPP1R50, B-cell CLL/lymphoma 2; BCL2L11/BIM, BCL2-like 11 (apoptosis facilitator); BECN1, Beclin 1, autophagy related; BNIP3, BCL2/adenovirus E1B 19 kDa interacting protein 3; BNIP3L/NIX, BCL2/adenovirus E1B 19 kDa interacting protein 3-like; DIA, diaphragm; EDL, extensor digitorium longus; EDTA, ethylenediaminetetraacetic acid; DTT, dithioreitol; FBXO32/ ATROGIN1, F-box protein 32; FOXO1, forkhead box O1; FOXO3, forkhead box O3; FOXO4, forkhead box O4; GABARAPL1, GABA(A) receptor-associated protein like 1; GP, gastrocnemius-plantaris; i.p., intraperitoneal; LAMP2A, lysosomal-associated membrane protein 2A; MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta; MTORC1, mechanistic target of rapamycin complex 1; PARK2, parkinson protein 2, E3 ubiquitin protein ligase (parkin); PBS, phosphate-buffered saline; PIK3C3, phosphatidylinositol 3-kinase, catalytic subunit type 3; PMSF, phenylmethylsulfonyl fluoride; PVDF, polyvinylidene difluoride ; RB1CC1/FIP200, RB1-inducible coiled-coil 1; ROS, reactive oxygen species; RPS6, ribosomal protein S6; RPS6KB1, ribosomal protein S6 kinase, 70 kDa, polypeptide 1; SEM, standard error of the mean; SOD1, superoxide dismutase 1, soluble; SOL, soleus; SQSTM1/p62, sequestosome 1; TA, tibialis anterior; TRAF6/RNF85, TNF receptor-associated factor 6, E3 ubiquitin protein ligase; TUBB, tubulin, beta class I; ULK1, unc-51 like autophagy activating kinase 1; UVRAG, UV radiation-resistance associated.

Original languageEnglish (US)
Pages (from-to)1604-1620
Number of pages17
Issue number10
StatePublished - Jan 1 2013


  • Autophagy
  • Fiber-type composition
  • Oxidative capacity
  • Skeletal muscles
  • Starvation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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