Autophagic flux and oxidative capacity of skeletal muscles during acute starvation

Mahroo Mofarrahi, Yeting Guo, Jeffrey A. Haspel, Augustine M.K. Choi, Elaine C. Davis, Gilles Gouspillou, Russell T. Hepple, Richard Godin, Yan Burelle, Sabah N.A. Hussain

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


ACTB, actin, beta; AKT, v-akt murine thymoma viral oncogene homolog; AMPK, 5'AMP-activated protein kinase; ANOVA, analysis of variance; ATG4B, autophagy-related 4B, cysteine peptidase; ATG5, autophagy-related 5; ATG7, autophagy-related 7; ATG12, autophagy-related 12; ATG13, autophagy-related 13; ATG14, autophagy-related 14; BCL2/ PPP1R50, B-cell CLL/lymphoma 2; BCL2L11/BIM, BCL2-like 11 (apoptosis facilitator); BECN1, Beclin 1, autophagy related; BNIP3, BCL2/adenovirus E1B 19 kDa interacting protein 3; BNIP3L/NIX, BCL2/adenovirus E1B 19 kDa interacting protein 3-like; DIA, diaphragm; EDL, extensor digitorium longus; EDTA, ethylenediaminetetraacetic acid; DTT, dithioreitol; FBXO32/ ATROGIN1, F-box protein 32; FOXO1, forkhead box O1; FOXO3, forkhead box O3; FOXO4, forkhead box O4; GABARAPL1, GABA(A) receptor-associated protein like 1; GP, gastrocnemius-plantaris; i.p., intraperitoneal; LAMP2A, lysosomal-associated membrane protein 2A; MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta; MTORC1, mechanistic target of rapamycin complex 1; PARK2, parkinson protein 2, E3 ubiquitin protein ligase (parkin); PBS, phosphate-buffered saline; PIK3C3, phosphatidylinositol 3-kinase, catalytic subunit type 3; PMSF, phenylmethylsulfonyl fluoride; PVDF, polyvinylidene difluoride ; RB1CC1/FIP200, RB1-inducible coiled-coil 1; ROS, reactive oxygen species; RPS6, ribosomal protein S6; RPS6KB1, ribosomal protein S6 kinase, 70 kDa, polypeptide 1; SEM, standard error of the mean; SOD1, superoxide dismutase 1, soluble; SOL, soleus; SQSTM1/p62, sequestosome 1; TA, tibialis anterior; TRAF6/RNF85, TNF receptor-associated factor 6, E3 ubiquitin protein ligase; TUBB, tubulin, beta class I; ULK1, unc-51 like autophagy activating kinase 1; UVRAG, UV radiation-resistance associated.

Original languageEnglish (US)
Pages (from-to)1604-1620
Number of pages17
Issue number10
StatePublished - Oct 2013


  • Autophagy
  • Fiber-type composition
  • Oxidative capacity
  • Skeletal muscles
  • Starvation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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