Automated brain tumor segmentation using spatial accuracy-weighted hidden Markov Random Field

Jingxin Nie, Zhong Xue, Tianming Liu, Geoffrey S. Young, Kian Setayesh, Lei Guo, Stephen T.C. Wong

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


A variety of algorithms have been proposed for brain tumor segmentation from multi-channel sequences, however, most of them require isotropic or pseudo-isotropic resolution of the MR images. Although co-registration and interpolation of low-resolution sequences, such as T2-weighted images, onto the space of the high-resolution image, such as T1-weighted image, can be performed prior to the segmentation, the results are usually limited by partial volume effects due to interpolation of low-resolution images. To improve the quality of tumor segmentation in clinical applications where low-resolution sequences are commonly used together with high-resolution images, we propose the algorithm based on Spatial accuracy-weighted Hidden Markov random field and Expectation maximization (SHE) approach for both automated tumor and enhanced-tumor segmentation. SHE incorporates the spatial interpolation accuracy of low-resolution images into the optimization procedure of the Hidden Markov Random Field (HMRF) to segment tumor using multi-channel MR images with different resolutions, e.g., high-resolution T1-weighted and low-resolution T2-weighted images. In experiments, we evaluated this algorithm using a set of simulated multi-channel brain MR images with known ground-truth tissue segmentation and also applied it to a dataset of MR images obtained during clinical trials of brain tumor chemotherapy. The results show that more accurate tumor segmentation results can be obtained by comparing with conventional multi-channel segmentation algorithms.

Original languageEnglish (US)
Pages (from-to)431-441
Number of pages11
JournalComputerized Medical Imaging and Graphics
Issue number6
StatePublished - Sep 2009


  • Brain tumor
  • MRI
  • Segmentation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Health Informatics
  • Radiological and Ultrasound Technology
  • Computer Graphics and Computer-Aided Design
  • Computer Vision and Pattern Recognition


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